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Postion:Product Catalog >Crizotinib hydrochloride
Crizotinib hydrochloride
  • Crizotinib hydrochloride

Crizotinib hydrochloride NEW

Price $31 $48 $101
Package 5mg 10mg 50mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-17

Product Details

Product Name: Crizotinib hydrochloride CAS No.: 1415560-69-8
Purity: 99.67% Supply Ability: 10g
Release date: 2024/11/17

Product Introduction

Bioactivity

名稱Crizotinib hydrochloride
描述Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met, with IC50 values of 20 nM and 8 nM, respectively.
體外活性Crizotinib hydrochloride(PF-2341066)potently inhibited NPM-ALK phosphorylation in Karpas299 or SU-DHL-1 ALCL cells (mean IC(50) value, 24 nmol/L).?In biochemical and cellular screens, PF-2341066 was shown to be selective for c-Met and ALK at pharmacologically relevant concentrations across a panel of >120 diverse kinases.?PF-2341066 potently inhibited cell proliferation, which was associated with G(1)-S-phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC(50) values, approximately 30 nmol/L) but not ALK-negative lymphoma cells[1].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 4.9 mg/mL (10.07 mM)
H2O : 50 mg/mL (102.71 mM), Sonication is recommended.
關(guān)鍵字Crizotinib Hydrochloride | PF02341066 Hydrochloride | CD246 | PF-02341066 | ROS Kinase | PF 02341066 Hydrochloride | Autophagy | ALK tyrosine kinase receptor | Anaplastic lymphoma kinase (ALK) | PF02341066 | Crizotinib hydrochloride | c-Met/HGFR | PF 02341066 | Crizotinib | Cluster of differentiation 246 | Inhibitor | PF-02341066 Hydrochloride | inhibit | Anaplastic lymphoma kinase
相關(guān)產(chǎn)品Stavudine | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Gefitinib
相關(guān)庫激酶抑制劑庫 | 酪氨酸激酶分子庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗癌上市藥物庫 | FDA 上市藥物庫 | FDA 上市激酶抑制劑庫 | 抗衰老化合物庫 | 抗癌藥物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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