Cobalt protoporphyrin IX NEW
| Price | $143 | $357 | $532 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Cobalt protoporphyrin IX | CAS No.: 14325-03-2 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Cobalt protoporphyrin IX |
| Description | Cobalt Protoporphyrin IX serves as a potent, specific inducer of heme oxygenase-1 (HO-1) and demonstrates broad-spectrum antiviral effects against Influenza A virus (IAV) [1]. |
| In vitro | Cobalt protoporphyrin IX demonstrated maximal non-toxic concentration (TC0) of 3.13 μM in both MDCK and RAW264.7 cells after 72 hours [1]. At 2 μM, with a treatment duration ranging from 0 to 24 hours, the compound increased HO-1 intracellular protein levels in a time-dependent manner in these cells [1]. With respect to influenza viruses Empty Cell A/FortMonmouth/1/1947, A/TianjinJinnan/15/2009, A/Wuhan/359/1995, A/FujianTongan/196/2009, and BY/FujianXinluo/54/2006, Cobalt protoporphyrin IX exhibited IC50 values of 0.40 ± 0.16, 0.42 ± 0.15, 0.46 ± 0.19, 0.34 ± 0.05, and 0.64 ± 0.30 μM, respectively [1]. At concentrations ranging from 0.25-2 μM for 18 or 24 hours, the compound inhibited IAV replication by enhancing the IFN response, an antiviral activity that was independent of the catalytic function of HO-1 [1]. Additionally, at 2 μM for 0-6 hours, Cobalt protoporphyrin IX induction of HO-1 antiviral activity may be dependent on the phosphorylation and translocation of IRF3, thereby strengthening the antiviral IFN response [1]. |
| Storage | Shipping with blue ice. |
| Inhibitors Related | Sodium Thiocyanate | Imeglimin hydrochloride | Acetylcysteine | L-Ascorbic acid | α-Vitamin E | Ammonium sulfate | Glucosamine | D-(+)-Glucono-1,5-lactone | Tempol | Lycopene | Coenzyme Q10 | Naringenin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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