CMS-121 NEW
Price | $37 | $57 | $107 |
Package | 5mg | 10mg | 25mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-07 |
Product Details
Product Name: CMS-121 | CAS No.: 1353224-53-9 |
Purity: 98.71% | Supply Ability: 10g |
Release date: 2024/11/07 |
Product Introduction
Bioactivity
名稱 | CMS-121 |
描述 | CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities. |
體外活性 | CMS-121 can increase acetyl-CoA in cells. CMS-121 (1 μM; 4 hours; HT22 cells) treatment also increases the phosphorylation of ACC1 at serine 79.[1]. |
體內(nèi)活性 | CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. CMS-121 (~20 mg/kg; p.o; daily; for 4 months; female SAMP8 mice) treatment decreases cognitive decline and metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. [1]. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 55 mg/mL (171.14 mM), Sonication is recommended. |
關(guān)鍵字 | ACC, Acetyl Coenzyme A Carboxylase | CMS 121 | disease | neuroprotective | inhibit | anti-inflammatory | mitochondrial | Alzheimer's | antioxidative | acetylation | Inhibitor | H3K9 | CMS-121 | Acetyl-CoA Carboxylase | dementia | ACC1 |
相關(guān)產(chǎn)品 | ND-646 | Olumacostat Glasaretil | PF-05175157 | Haloxyfop | CP-640186 hydrochloride | Firsocostat | PF-05221304 | CP-640186 | Quizalofop-P | Moiramide B | TOFA | Tralkoxydim |
相關(guān)庫 | 經(jīng)典已知活性庫 | 抗肥胖化合物庫 | 神經(jīng)保護化合物庫 | 抑制劑庫 | 口服活性化合物庫 | 代謝化合物庫 | 脂代謝化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 氧化還原化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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