CL 316243 NEW
| Price | $48 | $113 | $172 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: CL 316243 | CAS No.: 138908-40-4 |
| Purity: 99.68% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | CL 316243 |
| Description | CL316243 is a highly potent selective agonist of β3-adrenoceptor, with a EC50 of 3 nM. CL316243 is an effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence. |
| In vitro | METHODS: We treated rat adipocytes with CL (0.001 - 1 μM) and examined MAPK activation. RESULTS Treatment of cells with CL for 15 min activated MAPK, but the increase in MAPK activation was not obvious when treated with 1 nM CL, and disappeared when the concentration of CL was increased to 1 μM. [2] |
| In vivo | METHODS: The relaxant effects of different concentrations of CL316243 (0.25-100 g/kg) on the rat lower esophageal sphincter (LES) were recorded before and after continuous infusion of L748337 (0.5 g kg1 min1). RESULTS CL316243 had a significant, long-term and dose-dependent inhibitory effect on LESP, with little effect on heart rate and mean arterial pressure. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 80 mg/mL (171.75 mM), Sonication is recommended. |
| Keywords | inhibit | Adrenergic Receptor | Inhibitor | Beta Receptor | CL 316243 | CL-316243 | CL316243 |
| Inhibitors Related | Olanzapine | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Phenylephrine hydrochloride | Isoprenaline hydrochloride | Amitriptyline hydrochloride | Labetalol hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Obesity Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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