Chlorpheniramine maleate NEW
| Price | $30 |
| Package | 1mL |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Chlorpheniramine maleate | CAS No.: 113-92-8 |
| Purity: 99.67% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Chlorpheniramine maleate |
| Description | Chlorpheniramine maleate (NCI-C55265) is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. |
| Cell Research | Cells are exposed to various concentrations of Chlorpheniramine for 48 hours. Cells are washed, detached, and counted with a Coulter counter for the determination of cell growth.(Only for Reference) |
| Kinase Assay | H1-Antihistaminic Activity: The segments (1 cm) of isolated ileum from guinea pigs are suspended in an organ bath containing Tyrode solution (ventilation, 32 °C). The contractile responses to histamine (0.54 μM) are measured with an isotonic transducer. A set concentration of Chlorpheniramine is added in the organ bath 5 minutes before the addition of histamine. IC50 value of Chlorpheniramine is calculated by the probit methond. |
| In vitro | Oral administration of Chlorpheniramine (10 mg/kg) can suppress short-term scratching in BALB/c mice experiencing albumin-induced allergic skin irritation and ICR mice injected with histamine subcutaneously. Furthermore, in guinea pigs induced with histamine (ED50=0.17 mg/kg), oral intake of Chlorpheniramine prevents mortality. In rats, a dosage of Chlorpheniramine (20 mg/kg) is capable of blocking the histamine or cholinergic mechanisms that induce rapid eye movement (REM) sleep. |
| In vivo | Chlorpheniramine inhibits the binding of [3H] mepyramine to guinea pig cortical histamine H1 receptors (IC50=8.8 nM). It reduces ornithine decarboxylase mRNA translation in MCF-7, MDA-MB 231, and Ehrlich cells at a concentration of 250 μM, subsequently inhibiting cell proliferation. Chlorpheniramine displays antimalarial activity against Chloroquine-Sensitive (CQS) Plasmodium falciparum strain D6 (IC50=61.2uM) and Multidrug-Resistant (MDR) strain Dd2 (IC50=3.9uM). Furthermore, it exhibits cytotoxicity in mouse splenic lymphocytes induced by Concanavalin A (IC50=33.4 μM). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 50 mg/mL (127.92 mM) DMSO : 100 mg/mL (255.84 mM) |
| Keywords | Histamine Receptor | Chlorphenamine | Chlorpheniramine maleate | Chlorpheniramine Maleate | inhibit | NCI-C 55265 | Chlorpheniramine | Inhibitor | Chlorphenamine Maleate | NCI-C-55265 |
| Inhibitors Related | Meclizine dihydrochloride | Lidocaine | Famotidine | Sodium butanoate | Alginic acid |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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