Product Details
| Product Name:
CGP52411 |
CAS No.:
145915-58-8 |
| Purity:
99.56% |
Supply Ability:
10g |
| Release date:
2024/11/09 |
Product Introduction
Bioactivity
| 名稱 | CGP52411 |
| 描述 | CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramatically inhibits and reverses the formation of β-amyloid Aβ42 fibril aggregates. CGP52411 can be used in studies about Alzheimer's diseases. |
| 體外活性 | In A431 cells, CGP52411 (0-100 μM) dose-dependently inhibits autophosphorylation and c-src autophosphorylation with IC50s of 1 μM and 16 μM, respectively. CGP52411 reduces tyrosine phosphorylation of p185c-erbB2 in a concentration-dependent manner(IC50 = 10 μM)[1].
CGP52411 inhibits c-src kinase (IC50 = 16 μM) and PKC isozymes isolated from porcine brain (IC50 = 80 μM)[1]. |
| 體內(nèi)活性 | In female BALB/c nude mice, CGP52411 (6.3 mg/kg-50 mg/kg; orally) shows antitumor efficacy[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 90 mg/mL (273.3 mM), Sonication is recommended.
|
| 關鍵字 | CGP 52411 | CGP52411 | CGP-52411 |
| 相關產(chǎn)品 | Deferoxamine Mesylate | Osimertinib | Lidocaine Hydrochloride hydrate | Rutin | Lapatinib | Erlotinib hydrochloride | Erlotinib | Neratinib | Chalcone | Genistein | Gefitinib | Methyl tridecanoate |
| 相關庫 | 抗胰腺癌化合物庫 | 經(jīng)典已知活性庫 | 神經(jīng)信號分子庫 | 膜蛋白靶向化合物庫 | 酪氨酸激酶分子庫 | 激酶抑制劑庫 | 抗乳腺癌化合物庫 | 抗卵巢癌化合物庫 | 抑制劑庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:71861-76-2
$1980.00 / 50mg
-
-
CAS:73981-34-7
$335.00 / 5mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$39.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-09 |
United States