Product Details
| Product Name:
CGP48369 |
CAS No.:
135689-23-5 |
| Purity:
99.27% |
Supply Ability:
10g |
| Release date:
2024/11/20 |
Product Introduction
Bioactivity
| Name | CGP48369 |
| Description | CGP48369 is a potent angiotensin II receptor antagonist with antihypertensive effects that enhances endothelium-dependent relaxation of coronary arteries in spontaneously hypertensive rats. |
| In vitro | Binding to the AT1 receptor (IC50 1.8 nM in vascular smooth muscle cells, VSMC), CGP 48369 inhibits AII-induced contraction in rabbit aorta (IC50 8.7 nM)[2]. |
| In vivo | In two-kidney/one-clip renal hypertensive rats, CGP48369 (10 mg/kg/day p.o.) reduces blood pressure for at least 24 h. In arteries with endothelium, contractions induced by AII at 3×10-8 M do not differ between untreated spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. However, significantly smaller contractions are observed in SHR treated with CGP48369 compared to the other treated SHR groups. Antihypertensive treatment with benazepril or nifedipine, and to a lesser extent with CGP48369, increases sensitivity (pD2-value) to intraluminal ACh. In arteries without endothelium, sensitivity to NE is identical in all groups, while the maximal response in CGP48369-treated SHR and nifedipine-treated SHR is slightly greater compared to that in WKY[1]. In SHR, antihypertensive therapy with benazepril HCl, CGP48369, valsartan, or nifedipine (each 10 mg/kg/day for 8 weeks) significantly increases endothelium-dependent relaxations evoked by acetylcholine[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | CGP-48369 | CGP48369 | CGP 48369 |
| Inhibitors Related | Olmesartan Medoxomil | Tranilast | Enalapril Maleate | Azilsartan Methyl Ester | Sacubitril/Valsartan | Azilsartan | Sinapinic Acid | Irbesartan | Losartan | Ramipril | Captopril | Valsartan Methyl Ester |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
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