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Cergutuzumab amunaleukin NEW

Price	$428	$1090	$1780
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-15

Product Details

Product Name: Cergutuzumab amunaleukin	CAS No.: 1509916-03-3
Purity: 99.7% (SEC-HPLC)	Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱	Cergutuzumab amunaleukin
描述	Cergutuzumab amunaleukin (CEA-IL2v) is a CEA-targeted IL-2 variant immunocytokine for combination cancer immunotherapy with immunostimulatory and anti-tumor activities for the study of solid cancers.
體外活性	Cergutuzumab amunaleukin contains a single IL-2 variant (IL2V) part. The CD25 is abolished and blends to the high-end C-terminal. By removing the combination of CD25, Cergutuzumab amunaleukin can avoid priority activation of regulating T cells relative to immune effect cells. [1] Cergutuzumab amunaleukin activated the NK cells and converted into a killing of CEA-positive colon cancer cell line LS180, accompanied by the increase in the release of granase B, IFNγ, and RANTES, and the upward increase of CD25 and CD69 NK cells. [1]
體內(nèi)活性	Among the tumor-free mice treated with 0.5 and 2 mg/kg Cergutuzumab amunaleukin (i.v.; Once) the strong amplification of CD8+ T and NK cells after treatment. [1]
存儲條件	store at low temperature \| store at -20°C \| Shipping with blue ice.
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.