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Postion:Product Catalog >Centrinone
Centrinone
  • Centrinone

Centrinone NEW

Price $56 $77 $119
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-08

Product Details

Product Name: Centrinone CAS No.: 1798871-30-3
Purity: 98.76% Supply Ability: 10g
Release date: 2024/11/08

Product Introduction

Bioactivity

名稱Centrinone
描述Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).
體外活性Centrinone (LCR-263) treatment causes centrosome depletion in human and other vertebrate cells and it treatment reduces centriole number in multiciliated Xenopus epithelial cells, which indicates that Plk4 also controls centriole amplification in differentiated cells. Centrinone (LCR-263) treatment of HeLa human cervical carcinoma cells leads to a progressive reduction in foci containing centriolar and pericentriolar material markers at each round of cell division, until most cells lack centrioles and centrosomes. Centrosome loss irreversibly arrests normal cells in a senescence-like G1 state by a p53-dependent mechanism that is independent of DNA damage, stress, Hippo signaling, extends mitotic duration, or segregation errors[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 31 mg/mL (48.92 mM)
關(guān)鍵字LCR 263 | Polo-like Kinase (PLK) | LCR263 | Inhibitor | Centrinone | inhibit
相關(guān)產(chǎn)品Palmatine chloride | Onvansertib | T521 | Pyridoxine | 3MB-PP1 | SP600125 | KW-2449 | Palmatine | Alisertib | TAK-901 | Poloxin-2 | TCS7010
相關(guān)庫經(jīng)典已知活性庫 | 表觀遺傳庫 | 激酶抑制劑庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 細(xì)胞周期化合物庫 | 抗癌化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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