Product Details
| Product Name:
CD532 |
CAS No.:
1639009-81-6 |
| Purity:
99.49% |
Supply Ability:
10g |
| Release date:
2024/11/13 |
Product Introduction
Bioactivity
| 名稱 | CD532 |
| 描述 | CD532 is A highly potent Aurora A kinase inhibitor with an IC50 value of 45 nM. CD532 can block Aurora A kinase activity, drive MYCN degradation, and can directly interact with AURKA and induce global conformational transformation. CD532 can be used to study cancer. |
| 體外活性 | In MYCN-amplified neuroblastoma cell lines SK-N-BE(2) and Kelly, CD532 (1-10000 nM; 72 h) exhibits cytotoxicity with EC50s of 223.2 nM and 146.7 nM, respectively[1].
In SK-N-BE(2) cells, CD532 (0.1-1 μM; 24 h) causes a dose-dependent loss of MYCN protein[1].
Furthermore, CD532 (1 μM; 6 h) prevents S-phase entry in SK-N-BE(2) cells[1]. |
| 體內活性 | In mice with subcutaneous sonic hedgehog (SHH)-subtype medulloblastoma, CD532 (25 mg/kg; i.p. twice weekly for 3 weeks) decreases the tumor volume and increases survival[1].
In MYCN-amplified neuroblastoma xenografts, CD532 (60 mg/kg; i.p. for 2 days) reduces the level of MYCN protein[1].
CD532 (20 mg/kg; i.p.) in mice exhibits a serum half-life of ~1.5 hours and an AUC0-24 of 27 μM?h[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 200 mg/mL (382.76 mM), Sonication is recommended.
|
| 關鍵字 | CD532 | CD-532 | CD 532 | 1[4({4[(5cyclopentyl1Hpyrazol3yl)imino]1,4dihydropyrimidin2yl}amino)phenyl]3[3(trifluoromethyl)phenyl]urea | 1 [4 ({4 [(5 cyclopentyl 1H pyrazol 3 yl)imino] 1,4 dihydropyrimidin 2 yl}amino)phenyl] 3 [3 (trifluoromethyl)phenyl]urea |
| 相關產品 | Palmatine chloride | MK-8745 | SC-514 | MBM-55S | SP600125 | KW-2449 | Palmatine | Alisertib | TAK-901 | TCS7010 |
| 相關庫 | 經典已知活性庫 | 表觀遺傳庫 | 激酶抑制劑庫 | 抑制劑庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States