Product Details
| Product Name:
ccc_R08 |
CAS No.:
2919019-72-8 |
| Purity:
99.69% |
Supply Ability:
10g |
| Release date:
2024/11/12 |
Product Introduction
Bioactivity
| 名稱(chēng) | ccc_R08 |
| 描述 | ccc_R08 is an orally available HBV cccDNA inhibitor that reduces extracellular levels of HBV DNA, HBsAg, and HBeAg in a dose-dependent manner. ccc_R08 is investigational for use in the treatment of HBV infections. ccc_R08 has been shown to be effective in the treatment of hepatitis C virus (HCV). |
| 體外活性 | In HepDES19 cells, ccc_R08 (0.3, 1.0, 3.2, 10, 32 μM; 5 days) reduced the levels of cccDNA, protein-free RC-DNA, and double-stranded linear DNA (DL-DNA)[1]. |
| 體內(nèi)活性 | In the HBV circle mouse model, ccc_R08 (20 mg/kg; oral administration; twice daily for 2 weeks) led to the clearance of cccDNA from the livers of HBV circle mice[1]. |
| 存儲(chǔ)條件 | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 80 mg/mL (192.85 mM), Sonication is recommended.
|
| 相關(guān)產(chǎn)品 | Doxorubicin hydrochloride | Osthole | RO8191 | Tenofovir Disoproxil Fumarate | Thiamine hydrochloride | 4,5-Dicaffeoylquinic acid | 4-Hydroxyacetophenone | Telbivudine | Tenofovir | Bifendate |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$2500.00/100mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 |
United States