CBFβ Inhibitor NEW
| Price | $29 | $47 | $85 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-01 |
Product Details
| Product Name: CBFβ Inhibitor | CAS No.: 493028-20-9 |
| Purity: 96.50% | Supply Ability: 10g |
| Release date: 2024/11/01 |
Product Introduction
Bioactivity
| 名稱 | CBFβ Inhibitor |
| 描述 | CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1. |
| 體外活性 | The ELISA results have shown that CBFβ Inhibitor is very effective in inhibiting the CBFβ-Runx1 interaction (IC50: 3.2 μM). In the leukemia cell line ME-1 expressing CBFβ-SMMHC, CBFβ Inhibitor reduced cell proliferation dose-dependently. Treatment with CBFβ Inhibitor for 3 days showed an increase in apoptotic cells. Treatment with CBFβ Inhibitor for 14 days individually or with all-trans-retinoic acid (ATRA) resulted in cells with greater variation in size and shape, lower nuclear-to-cytoplasmic ratio, increased folding, and lobation of nuclei, and more clumped chromatin. All of these morphology changes are consistent with differentiation to more mature forms. CBFβ Inhibitor at 50 μM increased proliferation of Hep-G2 cells. CBFβ treatment with Inhibitor resulted in a statistically significant reduction in Runx1 bound to DNA [1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 25 mg/mL DMSO : 55 mg/mL (234.72 mM) |
| 關(guān)鍵字 | CBFbeta Inhibitor | CBFb Inhibitor | CBFβ Inhibitor |
| 相關(guān)產(chǎn)品 | Guanidine hydrochloride | Thymidine |
| 相關(guān)庫 | DNA 損傷和修復(fù)分子庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 細(xì)胞周期化合物庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| $68.00/1mg |
VIP3Y
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TargetMol Chemicals Inc.
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2024-11-07 | |
| $0.00/5Kg |
VIP1Y
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SHANGHAI GEM CHEMICAL INDUSTRY CO.,LTD.
|
2024-06-05 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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