Catharanthine NEW
| Price | $39 | $57 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: Catharanthine | CAS No.: 2468-21-5 |
| Purity: 99.55% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | Catharanthine |
| 描述 | Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions with an IC50 of 59.6 μM. |
| 體外活性 | Catharanthine evokes a concentration-dependent attenuation of carbachol responses in the rat ileum preparation, producing rightward curve displacements and decreases in maximal agonist responses. The mixture of serpentine, plus ajmalicine and catharanthine reveals a concentration-dependent inhibitory effect of acethylcholinesterase (AchE), with an IC50 at ca. 2.25 μg/mL. [1] Catharanthine can induce the self-association of tubulin into linear indefinite polymers with an efficacy that is 75% that of vinblastine or vincristine. Catharanthine binds to tubulin alpha-beta dimer with binding constant of 2.8 mM. [2] Catharanthine stimulates release of amylase from pancreatic fragments and to cause extensive degranulation of pancreatic acinar cells with accumulation of membrane material in the Golgi region. Catharanthine induces a delayed release of Ca2+ from prelabeled pancreatic fragments as compared to bethanechol. [3] Catharanthine inhibits epibatidine-induced Ca(2+) influx in TE671-α, -β, -γ, -δ cells in a noncompetitive manner with similar potencies IC50 of 17 mM-25 mM. Catharanthine inhibits [3H]TCP binding to the desensitized Torpedo AChR with higher affinity compared to the resting AChR. Catharanthine enhances [3H]cytisine binding to resting but activatable Torpedo AChRs, suggesting desensitizing properties. [4] |
| 存儲(chǔ)條件 | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 1 mg/mL (3 mM) DMSO : 40 mg/mL (118.9 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) |
| 關(guān)鍵字 | Calcium Channel | 3, 4-Didehydrocoronaridine | 3,4-Didehydrocoronaridine | Ca2+ channels | Ca channels | Inhibitor | inhibit | Catharanthine |
| 相關(guān)產(chǎn)品 | Adiphenine hydrochloride | Nisoldipine | Forskolin | L-Ascorbic acid | Ribavirin | Adenine | Ethyl cinnamate | 1-Octanol | Choline chloride | Propoxur |
| 相關(guān)庫 | 抗癌天然產(chǎn)物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 植物來源化合物庫 | 藥物功能重定位化合物庫 | 神經(jīng)保護(hù)化合物庫 | 抗癌上市藥物庫 | 已知活性化合物庫 | 離子通道庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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