Carnosic acid NEW
| Price | $40 | $74 | $123 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Carnosic acid | CAS No.: 3650-09-7 |
| Purity: 99.5% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Carnosic acid |
| Description | Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties. |
| Cell Research | Human dopaminergic neuroblastoma SH-SY5Y cells were cultured in Dulbecco's modified Eagle's medium (DMEM)/F-12 HAM nutrient medium (1:1 mixture; supplemented with 10% fetal bovine serum (FBS), 2 mM L-glutamine, penicillin (1000 units/mL), streptomycin (1000 μg/mL), and amphotericin B (2.5 μg/mL)) in a 5% CO2 humidified incubator at 37 °C. SH-SY5Y cells were cultured until a confluence of 80–90% was achieved and then trypsinized. H2O2 was utilized at 300 μM for different periods of incubation according to each specific assay. A pretreatment with CA (dissolved in DMSO) at 1 μM for 12 h was performed in order to test the ability of this diterpene in preventing the deleterious effects triggered by H2O2 in SH-SY5Y cells [2]. |
| Animal Research | Male C57BL/KsJ-db/db mice were given an intradermal injection of 100 μg of chicken type II collagen emulsified in complete Freund's adjuvant (1:1, w/v) into the base of the tail. 18 days after primary immunization, all mice showed signs of arthritis, and a booster, which consisted of 100 μg of chicken type II collagen emulsified in incomplete Freund's adjuvant (IFA; 1:1, v/v), was injected intradermally. All mice were divided into 7 groups; normal (Nor), db/db, db/db/CIA, and db/db/CIA with CA treatment. To investigate the effects of Carnosic acid (CA) on the development of arthritis, db/db mice and db/db/CIA mice were treated with 30 mg/kg body weight CA (CAL) and 60 mg/kg body weight CA (CAH) seven times per week for 4 weeks intraperitoneally after the booster injection. CA was prepared as 10 mmol/L stock solutions in DMSO [3]. |
| In vitro | ARPE-19 cells were pre-treated with 10 μM carnosic acid for 24 h followed by treatment with acrylamide (0.7 or 1 mM) for 24 h. ARPE-19 cells pre-treated with 10 μM carnosic acid showed significantly increased cell viability and decreased cell death rate when compared to ARPE-19 cells treated with acrylamide alone [1]. A pretreatment of human neuroblastoma SH-SY5Y cells with carnosic acid at 1 μM for 12 h prevented the hydrogen peroxide (H2O2)-induced impairment of the TCA enzymes (aconitase, α-ketoglutarate dehydrogenase (α-KGDH), succinate dehydrogenase (SDH)) and abolished the inhibition of the complexes I and V and restored the levels of ATP by a mechanism associated with Nrf2 [2]. |
| In vivo | Carnosic acid significantly down-regulated fasting blood glucose, glucose level in oral glucose tolerance test (OGTT) and insulin tolerance test (ITT), ameliorated CIA-induced bone loss, and reduced pro-inflammatory cytokines and reactive oxygen species (ROS) in db/db mice with arthritis induced by CIA [3]. |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 100 mg/mL (300.82 mM) H2O : Insoluble |
| Keywords | Inhibitor | inhibit | Carnosic acid | Bacterial | Apoptosis |
| Inhibitors Related | Neomycin sulfate | Stavudine | Dehydroacetic acid sodium | Ampicillin sodium | Dextran sulfate sodium salt (MW 4500-5500) | Kanamycin sulfate | Sodium 4-phenylbutyrate | Sulfamethoxazole sodium | Doxycycline | Tributyrin | Dimethyl sulfoxide | Oleic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Terpene Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Selected Plant-Sourced Compound Library | Inhibitor Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1kg |
VIP2Y
|
Hebei Kingfiner Technology Development Co.Ltd
|
2024-06-11 | |
| $18.00/10kg |
VIP1Y
|
Hebei Shengyang Water Conservancy Engineering Co., Ltd.
|
2024-05-10 | |
| $180.00/1kg |
VIP1Y
|
Hebei Zhuanglai Chemical Trading Co.,Ltd
|
2024-04-23 | |
| $0.00/1kg |
VIP1Y
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
2024-04-23 | |
| $0.00/1kg |
VIP1Y
|
BINBO BIOLOGICAL CO.,LTD
|
2024-04-11 | |
| $0.00/1KG |
Shaanxi Haibo Biotechnology Co., Ltd
|
2023-11-30 | ||
| $0.00/1kg |
VIP2Y
|
Wuhan Haorong Biotechnology Co.,Ltd
|
2023-08-02 | |
| $90.00/1kg |
Hebei baicao biology science and technology co., ltd
|
2022-05-05 | ||
| $0.00/1kg |
VIP3Y
|
Changsha Staherb Natural Ingredients Co., Ltd.
|
2022-04-03 | |
| $40.00/1KG |
VIP4Y
|
ZhenYiBio Technology Inc
|
2021-12-16 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY