Canertinib
Price | Get Latest Price | ||
Package | 1kg | 25kg | 100kg |
Min. Order: | 1kg |
Supply Ability: | 20tons |
Update Time: | 2025-01-03 |
Product Details
Product Name: Canertinib | CAS No.: 267243-28-7 |
Min. Order: 1kg | Purity: 99% |
Supply Ability: 20tons | Release date: 2025/01/03 |
Product Name | CAS 267243-28-7 Pharmaceutical Intermediate Canertinib |
CAS NO. | 267243-28-7 |
MF | C24h25clfn5o3 |
MW | 485.94 |
Melting Point | 188-190° |
Boiling Point | 691.0±55.0 °C(Predicted) |
Density | 1.355±0.06 g/cm3(Predicted) |
Appearance | White Powder |
Certificate | ISO, SGS, GMP, HACCP |
Assay Method | HPLC |
Extraction Type | Solvent Extraction |
Sample | Available |
MOQ | 1kg |
Shelf life | 2 Years |
Storage | Store in cool & dry place not freeze Keep away from strong light and heat |
Canertinib is
an irreversible quinazoline-based inhibitor of HER family tyrosine
kinases with IC50 values of 0.8, 19 and 7 nM for EGFR, HER2 and HER4,
respectively.
Canertinib irreversibly binds into the ATP
pocket within the TK domain of all erbB family members, where the
side-chain at position C6 of canertinib is brought into close proximity
with cysteines of erbB members, followed by the rapid formation of
a covalent bond, which permanently inactivates the catalytically active
erB1, erB2 and erB4 family members and effectively inhibits
erbB3-dependent signaling.
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- Since: 1996-07-16
- Address: Fujian China ,16F, Huicheng Comm. Complex, 839 Xiahe RD.