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Postion:Product Catalog >CaCCinh-A01
CaCCinh-A01
  • CaCCinh-A01

CaCCinh-A01 NEW

Price $52 $84 $189
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: CaCCinh-A01 CAS No.: 407587-33-1
Purity: 99.92% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameCaCCinh-A01
DescriptionCaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
Cell ResearchEach well of a 96-well plate is washed three times with PBS (200 μL/wash), leaving 50 μL of PBS. Test compounds (including CaCCinh-A01) (0.5 μL) are added to each well at 25 μM final concentration. After 10 min, 96-well plates are transferred to a plate reader for fluorescence assay. Each well is assayed individually for TMEM16A-mediated I- influx by recording fluorescence continuously (400 ms/point) for 2 s (baseline), then 50 μL of a 140 mM I-solution containing 200 μM ATP is added.
In vitroTannic acid (100 μM) and CaCCinh-A01 (30 μM) effectively inhibit CaCC current following ATP stimulation[1]. CaCCinh-A01 (0.1/1/10 μM) reduces Calcium-dependent chloride current (38±14, 66±10, and 91±1%). ATP-induced short-circuits currents are reduced by 38±7 and 78±3% at 10 and 30 μM CaCCinh-A01, respectively.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 55 mg/mL (158.31 mM)
KeywordsTMEM16A | infarction | inhibit | Inhibitor | neurological | CaCCinh-A-01 | CaCCinh-A01 | cerebral artery occlusion | CaCCinhA01 | Cl? Channels | Chloride Channel | CaCCinh A01 | deficit
Inhibitors RelatedSelamectin | D-Alanine | Niflumic acid | Urethane | Flufenamic acid | Lubiprostone | Halothane | Betaine chloride | Fenamic acid | Meticrane | Adjudin | Guanidinoethyl sulfonate
Related Compound LibrariesBioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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