Product Details
| Product Name:
BRD7389 |
CAS No.:
376382-11-5 |
| Purity:
99.17% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | BRD7389 |
| Description | BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. |
| In vitro | BRD7389 (1 μM) almost completely blocked Carbachol (1 mM)-stimulated cell proliferation, but has little effect on the basal level of proliferation[1]. BRD7389 (0.425, 0.85, 1.7, 3.4, 6.8 μM) induces insulin expression in mouse α-cells and induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM. BRD7389 increases β-cell-specific gene expression in primary human islet cells. BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 20 mg/mL (54.58 mM), Sonication and heating to 60℃ are recommended.
|
| Keywords | cancer | S6K | Inhibitor | colon | BRD 7389 | inhibit | RSK | islets | diabetes | pancreatic | SNU-407 | BRD-7389 | BRD7389 | Ribosomal S6 Kinase (RSK) |
| Inhibitors Related | Ribociclib | Gilteritinib | Nintedanib | Sorafenib | Pexidartinib | Sorafenib tosylate | CASIN | Palbociclib | Sodium Oxamate | Abemaciclib | Sodium salicylate | Dinaciclib |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Antidepressant Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Neuronal Differentiation Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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$195.00 / 1mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$46.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
United States