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Postion:Product Catalog >BMS453
BMS453
  • BMS453

BMS453 NEW

Price $58 $97 $217
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-06

Product Details

Product Name: BMS453 CAS No.: 166977-43-1
Purity: 99.78% Supply Ability: 10g
Release date: 2024/11/06

Product Introduction

Bioactivity

名稱BMS453
描述BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.
體外活性BMS453 (1 μM; 11 hours; 184 and HMEC cells) inhibits normal breast cell proliferation without significantly inducing apoptosis[2]. The RARβ-selective agonist (BMS453) significantly reduces T47D breast cancer cell migration to levels comparable to RA inhibition, unlike RARα- or RARγ-selective agonists (BMS753 and BMS961), indicating RARβ's role in RA-inhibited cell migration[3].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 45 mg/mL (118.27 mM)
關(guān)鍵字Inhibitor | retinoid | BMS-453 | RAR/RXR | BMS453 | inhibit | BMS189453 | TGFβ | breast | RARβ | RARγ | Retinoid X receptors | arrest | cell | RARα | BMS 189453 | Retinoic acid receptors
相關(guān)產(chǎn)品Isotretinoin | Oxybenzone | MSU-42011 | Tazarotene | Etodolac | KCL-286 | ER 50891 | Acitretin | Tamibarotene | Bexarotene | TTNPB | K-8012
相關(guān)庫核受體化合物庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 已知活性化合物庫 | 神經(jīng)元分化化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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