BMS 433796 NEW
| Price | $700 | $1800 |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-08 |
Product Details
| Product Name: BMS 433796 | CAS No.: 935525-13-6 |
| Purity: 99.17% | Supply Ability: 10g |
| Release date: 2024/11/08 |
Product Introduction
Bioactivity
| 名稱 | BMS 433796 |
| 描述 | BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity in a transgenic mouse model of Alzheimer's disease. |
| 體外活性 | BMS-433796 causes a concentration-dependent decrease in [3H]IN973 binding, with an IC50 value of 1.2 nM, which is very similar to the IC50 values for the inhibition of Aβ40 (0.8 nM) and Aβ42 (0.4 nM) in human embryonic kidney cells overexpressing the Swedish mutation of APP[1]. |
| 體內(nèi)活性 | Characterized in pharmacokinetic studies in male Sprague-Dawley rats, BMS-433796 shows low clearance with a total body clearance of 5.2±0.82 mL/min/kg (means±SEM; n=3) following a 10-minute intravenous infusion at 2.3 μmol/kg in PEG-400. The apparent terminal elimination half-life is 4.6±0.48 h. Upon oral administration of a PEG-400 suspension at 35 μmol/kg, BMS-433796 exhibits an oral bioavailability of 31% with prolonged absorption. BMS-433796 demonstrates satisfactory metabolic stability in human liver microsomal preparations and is not an inhibitor of human CYPs (IC50>100 μM)[2]. The reduction of brain Aβ40 is dose-dependent upon administering BMS-433796, with an ED50 value of 2.4 mg/kg[1]. |
| 存儲條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 關鍵字 | BMS 433796 | BMS-433796 | BMS433796 |
| 相關產(chǎn)品 | Anle138b | BSBM7 | Notoginsenoside R1 | Geniposide | Deferoxamine Mesylate | Tramiprosate | PQM130 | Dihydroergocristine mesylate | Rutin | Ginsenoside Rg2 | Methyl tridecanoate | Ginsenoside Re |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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