Bilirubin NEW
| Price | $42 | $59 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: Bilirubin | CAS No.: 635-65-4 |
| Purity: ≥98% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | Bilirubin |
| 描述 | Bilirubin (Principal bile pigment) is a type of bile pigment, which is a metabolite of hemoglobin in the blood. Bilirubin has antimutagenic and antioxidant effects. Bilirubin is an important basis for clinical determination of jaundice, and is also an important indicator of liver function. |
| 體外活性 | METHODS: PDAC cells SW1990 and MIA PaCa2 were treated with BAY-598 (10 μM) and doxorubicin (1 μM) for 48 h. Cell viability was determined by MTT assay. RESULTS: PDAC cells were highly sensitive to acute treatment with the low-dose combination of doxorubicin and BAY-598. [1] |
| 體內(nèi)活性 | METHODS: To detect anti-tumor activity in vivo, BAY-598 (50 mg/kg once daily) and gemcitabine (100 mg/kg every three days) were injected intraperitoneally into NSG mice bearing SW1990 xenografts for 27 days. RESULTS: The combination of gemcitabine and BAY-598 attenuated the growth of SW1990 xenografts compared to monotherapy. [1] METHODS: To detect anti-tumor activity in vivo, BAY-598 (10-100 mg/kg, PEG 400/water 8:2) was administered orally to BALB/c nude mice bearing KYSE-150 xenografts once daily for three days. RESULTS: BAY-598 was able to inhibit SMYD2 methylation activity in tumor cells in vivo. [2] |
| 存儲條件 | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 5.84 mg/mL (10 mM), Sonication is recommended. |
| 關(guān)鍵字 | Endogenous Metabolite | Bilirubin | antimutagenic | antioxidant | catabolism | heme | inhibit | Inhibitor |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 藥物功能重定位化合物庫 | 天然產(chǎn)物庫 | 高通量篩選天然產(chǎn)物庫 | 抗衰老化合物庫 | 人內(nèi)源代謝化合物庫 | 已知活性化合物庫 | 腸道微生物代謝化合物庫 | 抗COVID-19化合物庫 | 小鼠代謝化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36?Washington?Street, Wellesley?Hills
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