Bifonazole NEW
Price | $10 | $6 | $2 |
Package | 1KG | 100KG | 1000KG |
Min. Order: | 1KG |
Supply Ability: | g-kg-tons, free sample is available |
Update Time: | 2024-04-28 |
Product Details
Product Name: Bifonazole | CAS No.: 60628-96-8 |
Min. Order: 1KG | Purity: 99% |
Supply Ability: g-kg-tons, free sample is available | Release date: 2024/04/28 |
Lead time: In stock | Packaging: bottle/drum/bucket/IBC, as request. |
Delivery: By sea, by air, by express | Origin: Manufacturer |
1. Product information
Name | 1-[phenyl-(4-phenylphenyl)methyl]imidazole |
---|---|
Synonym | More Synonyms |
Description | Bifonazole is an imidazole antifungal drug.Target: AntifungalBifonazole, a new broad-spectrum antimycotic, interferes with sterol biosynthesis. In dermatophytes bifonazole additionally inhibits directly HMG-CoA-reductase. bifonazole possesses a sequential mode of action, namely inhibition of cytochrome P450-dependent C14-demethylation of sterols and direct inhibition of HMG-CoA-reductase. In vitro bifonazole shows a strongly pH-dependent efficacy. The uptake kinetics of bifonazole have been measured with different pathogens [1]. Bifonazole additionally leads to a generally decreased rate of sterol biosynthesis as compared to clotrimazole, due to a direct inhibition of microsomal HMG-CoA-reductase. The additional fungicidal effects of bifonazole are considered to originate from a sequential action by inhibition of HMG-CoA-reductase and of cytochrome P450 [2]. bifonazole were affected by choice of medium with Kimmig's agar generally giving the lowest MIC's. Bifonazole MICs were shown to vary with pH (maximal activity at pH 6 . 5) with selected yeasts when tested on Kimmig's agar [3]. |
---|---|
Related Catalog | Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection |
References | [1]. Berg, D. and M. Plempel, Bifonazole, a biochemist's view. Dermatologica, 1984. 169 Suppl 1: p. 3-9. [2]. Berg, D., et al., Bifonazole and clotrimazole. Their mode of action and the possible reason for the fungicidal behaviour of bifonazole. Arzneimittelforschung, 1984. 34(2): p. 139-46. [3]. Shadomy, S., D.M. Dixon, and R. May, A comparison of bifonazole (BAY H 4502) with clotrimazole in vitro. Sabouraudia, 1982. 20(4): p. 313-23. |
Density | 1.1±0.1 g/cm3 |
---|---|
Boiling Point | 491.7±24.0 °C at 760 mmHg |
Melting Point | 142℃ |
Molecular Formula | C22H18N2 |
Molecular Weight | 310.392 |
Flash Point | 251.2±22.9 °C |
Exact Mass | 310.147003 |
PSA | 17.82000 |
LogP | 4.84 |
Vapour Pressure | 0.0±1.2 mmHg at 25°C |
Index of Refraction | 1.616 |
2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
For more details, pls contact us freely.
Mob: 86 17630971917
WhatsApp/Skype/Wechat/LINE: 86 17630971917
Company Profile Introduction
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$31.00/1g |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-10-29 | |
$31.00/1g |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-29 | |
$10.50/1KG |
VIP4Y
|
Hebei Chuanghai Biotechnology Co,.LTD
|
2024-08-21 | |
$0.00/1kg |
VIP1Y
|
airuikechemical co., ltd.
|
2024-04-10 | |
$70.00/1kg |
VIP2Y
|
Zibo Hangyu Biotechnology Development Co., Ltd
|
2023-10-27 | |
$30.00/1kg |
Anhui Ruihan Technology Co., Ltd
|
2023-09-12 | ||
$0.00/25Kg/Drum |
Guangzhou Dihao Medical Technology Co., Ltd
|
2021-09-22 | ||
$0.00/25Kg/Drum |
VIP4Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2021-07-29 | |
$1.10/1g |
VIP4Y
|
Dideu Industries Group Limited
|
2021-07-19 | |
$15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-08 |
- Since: 2023-02-10
- Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro