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Postion:Product Catalog >Biochemical Engineering>Natural Products>Betulin
Betulin
  • Betulin

Betulin NEW

Price $50 $72
Package 50mg 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Betulin CAS No.: 473-98-3
Purity: 99.9% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameBetulin
DescriptionBetulin (betulinol) (lup-20(29)-ene-3β, 28-diol) is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees where it forms up to 30% of the dry weight of the extractive and is found in birch sap as well.
Cell ResearchChemoresistance is tested using a proliferation assay based on sulphorhodamine B staining. Briefly, 800 cells per well are seeded in triplicate in 96-well plates. After attachment for 24 h, substances are added in dilution series for a 5-day incubation, before SRB staining is performed. Incubation is terminated by replacing the medium with 10% trichloroacetic acid, followed by further incubation at 4°C for 1h. Subsequently, the plates are ished five times with water and stained by adding 100 μL 0.4% SRB in 1% acetic acid for 10 min at room temperature. Ishing the plates five times with 1% acetic acid eliminated unbound dye. After air-drying and re-solubization of the protein bound dye in 10 mM Tris-HCl (pH=8.0), absorbance is read at 562 nm[2].
In vitroBetulin (BE) is recognized for its extensive biological and pharmacological benefits, notably its anticancer and chemopreventive capabilities, which have garnered substantial interest. Research indicates that BE impedes the growth of cancer cells across various cancer types, showing a range of antiproliferative effects—from minimal in human erythroleukaemia cells (K562) to pronounced in human neuroblastoma cells (SK-N-AS). Additionally, BE demonstrates marked cytotoxicity towards primary cancer cell cultures from ovarian, cervical carcinoma, and glioblastoma, with IC50 values between 2.8 to 3.4 μM, notably lower than those in established cell lines. Comparative studies of crude birch bark extract, alongside purified betulin and betulinic acid, reveal significant efficacy against human gastric carcinoma (EPG85-257) and human pancreatic carcinoma (EPP85-181), including drug-sensitive and drug-resistant types, indicating their potential as promising therapeutic agents for cancer treatment.
In vivoBetulin enhances glucose intolerance, augments basal learning performance, and notably ameliorates oxidative stress by significantly restoring SOD activity while reducing MDA levels in the hippocampus. Further, it significantly mitigates serum and hippocampal inflammatory cytokines. Betulin administration also upregulates Nrf2 and HO-1 expressions and inhibits IκB and NF-κB phosphorylations. Overall, Betulin potentially offers cognitive protection against STZ-induced diabetes in rats through the HO-1/Nrf-2/NF-κB pathway[3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : Insoluble
KeywordsFatty Acid Synthase (FASN) | inhibit | Endogenous Metabolite | Apoptosis | Inhibitor | Betulin
Related Compound LibrariesTraditional Chinese Medicine Monomer Library | Drug Repurposing Compound Library | Miao medicine Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Natural Product Library for HTS | Anti-virus Traditional Chinese Medicine Monomer Library | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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