Berberine NEW
| Price | $50 |
| Package | 20mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Berberine | CAS No.: 2086-83-1 |
| Purity: 99.38% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Berberine |
| 描述 | 1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3. Berberine seems to act as an herbal antidepressant and a neuroprotector against neurodegenerative disorders. 4. Berberine is used in histology for staining heparin in mast cells. As a natural dye, berberine has a colour index of 7516. 5. Berberine reduces hepatic fat content in rats with nonalcoholic fatty liver disease; also prevents proliferation of hepatic stellate cells (HSCs), which are central for the development of fibrosis during liver injury. 6. Berberine can ameliorate proinflammatory cytokines-induced intestinal epithelial tight junction damage in vitro, and berberine may be one of the targeted therapeutic agents that can restore barrier function in intestinal disease states. 7. Berberine has antineoplastic effects, including breast cancer, leukemia, melanoma, epidermoid carcinoma, hepatoma, pancreatic cancer, oral carcinoma, tongue carcinoma, glioblastoma, prostate carcinoma and gastric carcinoma, etc. |
| 體外活性 | METHODS: Human osteosarcoma cells MG-63 were treated with Berberine (20-80 μM) for 12-24 h. Cell viability was measured by MTT assay. RESULTS: Berberine induced a concentration- and time-dependent decrease in MG-63 cell viability. [1] METHODS: The NPC cell line HONE1 was treated with Berberine (25-50 μM) for 24 h, and the expression levels of target proteins were measured by Western Blot. RESULTS: Berberine effectively inhibited the level of p-STAT3 in HONE1 cells, and the down-regulation of STAT3 activation was associated with the inhibition of Mcl-1 expression and an increase in cleaved PARP-1 levels. [2] |
| 體內(nèi)活性 | METHODS: To test the antitumor activity in vivo, Berberine (5-10 mg/kg) was injected intraperitoneally every two days for thirty days into nude mice bearing NPC tumor C666-1. RESULTS: Berberine effectively inhibited the tumorigenicity and growth of EBV-positive NPC cell line (C666-1) in nude mice. Inhibition of tumorigenic growth of NPC cells in vivo correlated with effective inhibition of STAT3 activation in NPC cells within tumor xenografts in nude mice. [2] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.05 mg/mL (6.09 mM), Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc. : Soluble DMSO : 5.63 mg/mL (16.72 mM), Sonication is recommended. H2O : ＜1 mg/mL (insoluble) |
| 關(guān)鍵字 | Bacterial | Endogenous Metabolite | Inhibitor | inhibit | Reactive Oxygen Species | Natural Yellow18 | Topoisomerase | Antibiotic | Autophagy | Natural Yellow-18 | Natural Yellow 18 | Berberine |
| 相關(guān)產(chǎn)品 | Sucrose | Neomycin sulfate | Sulfamethoxazole sodium | Hydroxychloroquine | Ferulic Acid | Glycerol | Thymidine | Dimethyl sulfoxide |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 中藥單體化合物庫 | 生物堿類天然產(chǎn)物庫 | 藥物功能重定位化合物庫 | 抗寄生蟲天然產(chǎn)物庫 | 抗衰老化合物庫 | 抗感染天然產(chǎn)物庫 | 抗病毒中藥單體化合物庫 | 抗癌藥物庫 | 藥食同源庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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