Benztropine mesylate NEW
| Price | $29 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Benztropine mesylate | CAS No.: 132-17-2 |
| Purity: 99.52% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Benztropine mesylate |
| 描述 | Benztropine mesylate (Benztropine methanesulfonate) is a centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine. |
| 體外活性 | At doses of 5 mg/kg and 25 mg/kg, Benztropine increases the levels of extracellular dopamine in the striatum of rats in a dose-dependent manner. A daily dose of 3 mg of Benztropine effectively improves tremor and motor scores in patients with Parkinson's disease on the Unified Parkinson's Disease Rating Scale without causing adverse effects such as leukopenia. |
| 體內(nèi)活性 | In HEK-293 cells treated with [3H]CFT and under the condition of 130 mM sodium ions, the D313N DAT exhibited a slight increase in the apparent equilibrium dissociation constant for Benztropine. The double mutant W84L D313N DAT showed a similar apparent equilibrium dissociation constant for Benztropine when compared to the single mutation. Benztropine inhibited MTSET-induced binding of [3H]WIN to the wild-type dopamine transporter with an EC50 of 28 μM in a concentration-dependent manner. Furthermore, Benztropine demonstrated a protection rate of 32 in the X-A342C DAT construct by shielding Cys-342 from reactivity (EC50 for inhibition of [3H]WIN (4 nM) to IC50 binding). |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 74 mg/mL (183.4 mM) DMSO : 45 mg/mL (111.52 mM), Sonication is recommended. Ethanol : 75 mg/mL (185.9 mM) |
| 關(guān)鍵字 | Benzotropine | Benzotropine Mesylate | disease | Benzatropine | anti-histamine | Histamine Receptor | inhibit | Benztropine | Muscarinic acetylcholine receptor | Parkinson's | anticholinergic | mAChR | Benzatropine Mesylate | Benztropine Mesylate | Benztropine mesylate | dopamine | Dopamine Receptor | transporter | Inhibitor |
| 相關(guān)產(chǎn)品 | Adiphenine hydrochloride | Meclizine dihydrochloride | Ribavirin | Lidocaine | Famotidine | Octopamine hydrochloride | Adenine | Choline chloride | Propoxur | Alginic acid |
| 相關(guān)庫 | 神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 疼痛相關(guān)化合物庫 | 抑制劑庫 | 抗癌上市藥物庫 | FDA 上市藥物庫 | 已知活性化合物庫 | GPCR靶點(diǎn)分子庫 | 抗癌藥物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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