BAY-85-8501 NEW
| Price | $88 | $223 | $331 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: BAY-85-8501 | CAS No.: 1161921-82-9 |
| Purity: 98.63% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | BAY-85-8501 |
| 描述 | BAY-85-8501 is a selective, reversible, and potent inhibitor of Human Neutrophil Elastase (HNE) with an IC50 of 65 pM. |
| 體內(nèi)活性 | In this study, the exogenous compound HNE noxa is identified as the primary cause of lung injury and hemorrhage. BAY-85-8501 (29), due to its picomolar potency against HNE and high effectiveness against MNE, completely prevents lung injury and subsequent inflammation if administered one hour before exposure to HNE noxa. Despite its high selectivity for HNE inhibition, BAY-85-8501 does not prevent primary lung injury caused by PPE since it has no effect on it. However, BAY-85-8501 can inhibit MNE, an endogenous promoter of inflammation and secondary lung injury, albeit with lower potency. The prevention of inflammation and secondary injury by BAY-85-8501 is less pronounced and requires doses 30 times higher than standard. Its effectiveness primarily relies on its ability to inhibit MNE (Ki=6 nM) in these cases. At a dosage of 0.01 mg/kg, a significant reduction in hemoglobin concentration is noted, and at 0.1 mg/kg, a notable decrease in neutrophil count is observed, indicating efficacy is largely dependent on its potency against HNE (Ki=0.08 nM) in this scenario. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 200 mg/mL (421.53 mM), Sonication is recommended. |
| 關(guān)鍵字 | inhibit | Elastase | BAY-85-8501 | Inhibitor | BAY 85 8501 | BAY858501 |
| 相關(guān)產(chǎn)品 | PMSF | Nafamostat mesylate | Diminazene Aceturate | AEBSF hydrochloride | 2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one | Leupeptin Hemisulfate | Ceritinib | Aprotinin | Sivelestat | 4-Aminobenzamidine dihydrochloride | 2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- | Benzamidine hydrochloride |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | ReFRAME 相關(guān)化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 | 共價抑制劑庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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