Azvudine NEW
Price | $57 | $139 | $230 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-06 |
Product Details
Product Name: Azvudine | CAS No.: 1011529-10-4 |
Purity: 99.42% | Supply Ability: 10g |
Release date: 2024/11/06 |
Product Introduction
Bioactivity
名稱 | Azvudine |
描述 | Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). |
體外活性 | Azvudine is sensitive to NRTIs-resistant strain HIV-174V, PIs-resistant strains HIV-1L10R/M46I/L63P/V82T/I84V and HIV-1RF V82F/184V, and FIs-resistant strain pNL4-3 gp41 (36G) V38A/N42T. The EC50 values of Azvudine against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively[1]. Azvudine displays strong inhibition on wild-type HIV-1IIIB and HIV-1RF with an EC50 ranging from 30 to 110 pM. The EC50 values of Azvudine against HIV-1KM018, HIV-1TC-1 and HIV-1WAN T69N are 6.92, 0.34 and 0.45 nM, respectively. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 5.2 mg/ml (18.17 mM) H2O : 50 mg/mL |
關鍵字 | resistant | Human immunodeficiency virus | NRTI | inhibit | mutation | RO 0622 | Inhibitor | Reverse Transcriptase | HCV | Hepatitis C virus | Azvudine | Hepatitis B virus | HIV | analogue | HBV | RO0622 |
相關產(chǎn)品 | Stavudine | 5-Fluorouracil | Emtricitabine | Kaempferol | Dolutegravir intermediate-1 | Dextran sulfate sodium salt (MW 4500-5500) | Lamivudine | Cetylpyridinium Chloride | Chloroquine phosphate | Artemisinin | Decanedioic acid | Tenofovir |
相關庫 | 經(jīng)典已知活性庫 | ReFRAME 相關化合物庫 | 藥物功能重定位化合物庫 | 抗病毒庫 | 抑制劑庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 | 抗感染化合物庫 | 人代謝物化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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