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Postion:Product Catalog >Azvudine
Azvudine
  • Azvudine

Azvudine NEW

Price $57 $139 $230
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-06

Product Details

Product Name: Azvudine CAS No.: 1011529-10-4
Purity: 99.42% Supply Ability: 10g
Release date: 2024/11/06

Product Introduction

Bioactivity

名稱Azvudine
描述Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
體外活性Azvudine is sensitive to NRTIs-resistant strain HIV-174V, PIs-resistant strains HIV-1L10R/M46I/L63P/V82T/I84V and HIV-1RF V82F/184V, and FIs-resistant strain pNL4-3 gp41 (36G) V38A/N42T. The EC50 values of Azvudine against these resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectively[1]. Azvudine displays strong inhibition on wild-type HIV-1IIIB and HIV-1RF with an EC50 ranging from 30 to 110 pM. The EC50 values of Azvudine against HIV-1KM018, HIV-1TC-1 and HIV-1WAN T69N are 6.92, 0.34 and 0.45 nM, respectively.
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 5.2 mg/ml (18.17 mM)
H2O : 50 mg/mL
關鍵字resistant | Human immunodeficiency virus | NRTI | inhibit | mutation | RO 0622 | Inhibitor | Reverse Transcriptase | HCV | Hepatitis C virus | Azvudine | Hepatitis B virus | HIV | analogue | HBV | RO0622
相關產(chǎn)品Stavudine | 5-Fluorouracil | Emtricitabine | Kaempferol | Dolutegravir intermediate-1 | Dextran sulfate sodium salt (MW 4500-5500) | Lamivudine | Cetylpyridinium Chloride | Chloroquine phosphate | Artemisinin | Decanedioic acid | Tenofovir
相關庫經(jīng)典已知活性庫 | ReFRAME 相關化合物庫 | 藥物功能重定位化合物庫 | 抗病毒庫 | 抑制劑庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 | 抗感染化合物庫 | 人代謝物化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
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