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Postion:Product Catalog >API>Blood System Drugs>Anticoagulant and Antiplatelet Drugs>Argatroban
Argatroban
  • Argatroban

Argatroban NEW

Price $33 $54 $105
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Argatroban CAS No.: 74863-84-6
Purity: 99.77% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameArgatroban
DescriptionArgatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
In vitroIn a rat distal cerebral artery occlusion model, administration of Argatroban at a dose of 0.3 mg/hour significantly reduced the number of microthrombi following artery occlusion. Argatroban treatment (at 0.1 and 0.3 mg/hour) notably reversed the decline in local cerebral blood flow in rats with distal cerebral artery occlusion.
In vivoArgatroban directly induces phenotypic transformation in vascular smooth muscle cells, upregulating the expression of myofilament-related proteins, PAI-1, and β-actin mRNA. In animal models with thrombosis rich in platelets and erythrocytes, Argatroban (ED50=125 μg/kg) demonstrates antithrombotic effects. It exhibits antithrombin activity across a range (Ki=5 nM-39 nM).
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationEthanol : 6 mg/mL (11.79 mM)
DMSO : 45 mg/mL (88.47 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
KeywordsMCI9038 | Argatroban | MD805 | MCI 9038 | inhibit | Inhibitor | MD 805 | Thrombin
Inhibitors RelatedDabigatran Etexilate Mesylate | (S)-(+)-Ibuprofen | Edoxaban | AEBSF hydrochloride | Heparin sodium salt | Thrombin (MW 37kDa) | Menadione | Ozagrel | Eltrombopag Olamine | p-Hydroxycinnamic acid
Related Compound LibrariesFDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | Human Metabolite Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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