Arecoline hydrobromide NEW
| Price | $5 | $0.1 |
| Package | 1KG | 1000KG |
| Min. Order: | 1KG |
| Supply Ability: | g-kg-tons, free sample is available |
| Update Time: | 2024-04-16 |
Product Details
| Product Name: Arecoline hydrobromide | CAS No.: 300-08-3 |
| Min. Order: 1KG | Purity: 99% |
| Supply Ability: g-kg-tons, free sample is available | Release date: 2024/04/16 |
| Lead time: In stock, ready for shipment | Packaging: bag/bottle/drum/IBC |
| Delivery: By express, by air, by sea | Origin: Manufacturer, advantage product |
| COA, MSDS: Available, contact us for details | Name: Tina |
1. Materials information
| Name | methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate,hydrobromide |
|---|---|
| Synonym | More Synonyms |
| Description | Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist. Target: mAChRArecoline is an alkaloid found in the areca nut. Arecoline. a drug obtained from the Areca Catechu L., induced a dose-dependent antinociception (0.3-1 mg kg(-1) i.p.) which was prevented by the muscarinic antagonists pirenzepine (0.1 microg per mouse i.c.v.) and S-(-)-ET-126 (0.01 microg per mouse i.c.v.) [1]. Arecoline exerts its excitatory actions by binding to M2-muscarinic receptors on the cell membrane of neurons of the locus coeruleus [2]. Arecoline (1 nM - 1 microM) produced a concentration-dependent contraction in both the longitudinal and the circular smooth muscle of rabbit colon. Atropine (10 microM) abolished the arecoline (80 nM)--induced contraction. M3 receptor antagonist, 4 - DAMP (0.4 microM), abolished the arecoline (80 nM)--related response, whereas M2 receptor antagonist, gallamine (0.4 microM), did not affect the effect of arecoline. These results suggest that arecoline excites the colonic motility via M3 receptor in rabbits [3]. |
|---|---|
| Related Catalog | Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease |
| References | [1]. Ghelardini, C., et al., M1 receptor activation is a requirement for arecoline analgesia. Farmaco, 2001. 56(5-7): p. 383-5. [2]. Yang, Y.R., et al., Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor. Chin J Physiol, 2000. 43(1): p. 23-8. [3]. Xie, D.P., et al., Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits. Chin J Physiol, 2004. 47(2): p. 89-94. |
| Boiling Point | 209oC at 760mmHg |
|---|---|
| Melting Point | 171-175 °C |
| Molecular Formula | C8H14BrNO2 |
| Molecular Weight | 236.106 |
| Flash Point | 81.1oC |
| Exact Mass | 235.020782 |
| PSA | 29.54000 |
| LogP | 1.31730 |
| Storage condition | Refrigerator |
| Water Solubility | H2O: 0.1 g/mL, clear, colorless |
Arecoline hydrobromide MSDS(Chinese) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |  GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | S45-S38-S36/37/39-S28A |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | QT2275000 |
| HS Code | 29399990 |
| Precursor 0 | |
|---|---|
| DownStream 10 | Previous 1/3 Next |
| |
CAS#:6027-91-4
CAS#:498-96-4
CAS#:499-04-7
CAS#:26070-52-0| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Determination and pharmacokinetic studies of arecoline in dog plasma by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 12-8, (2014) A rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of arecoline concentration in dog plasma. Plas... | |
| Arecoline is cytotoxic for human endothelial cells. J. Oral. Pathol. Med. 43(10) , 761-9, (2014) Oral submucous fibrosis is a pre-malignant fibrotic condition caused by areca nut use and involves reduced mucosal vascularity. Arecoline is the principal areca nut alkaloid and is cytotoxic for epith... |
| 1-Methyl-1,2,5,6-tetrahydro-pyridin-3-carbonsaeure-methylester,Hydrobromid |
| MFCD00039041 |
| Methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide (1:1) |
| EINECS 206-087-3 |
| Arecaidine methyl ester hydrobromide |
| methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide |
| 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide (1:1) |
| Arecoline |
| Methyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrobromide |
| ARECOLINE HBr |
| Methyl 1,2,5,6-Tetrahydro-1-methylnicotinate Hydrobromide |
| Methyl-1-methyl-1,2,5,6-tetrahydro-3-pyridincarboxylathydrobromid |
| 1-methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester,hydrobromide |
| arecolinium bromide |
| Methyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrobromide (1:1) |
| Arecoline hydrobromide |
| Taeniolin |
| Arecoline bromide |
| 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic Acid Methyl Ester Hydrobromide |
| 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide (9CI) |
| 1-Méthyl-1,2,5,6-tétrahydro-3-pyridinecarboxylate de méthyle bromhydrate |
| Arecoline (hydrobromide) |
2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
By Express
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
By Air
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
By Sea
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
For more details, pls contact us freely.
Email address: Tina@fdachem.com
Mob: 86 13213167925
WhatsApp/Skype/Wechat/LINE: 86 13213167925
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China
- Since: 2023-02-10
- Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro