Product Details
Product Name: Apixaban | CAS No.: 503612-47-3 |
EC-No.: 639-684-6 | Min. Order: 1kg |
Purity: 98% | Supply Ability: 20 tons |
Release date: 2024/11/01 |
Generic name: Apixaban
Brand names: Eliquis, Eliquis Starter Pack for Treatment of DVT and PE
Oral tablet in 2.5 mg and 5 mg strengths.
For patients with nonvalvular atrial fibrillation to reduce the risk of stroke and systemic embolism.
For the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE).
Prophylaxis of DVT, which may lead to PE, in patients who have undergone knee or hip replacement surgery.
Reducing the risk of recurrent DVT and PE after initial therapy.
Apixaban is a direct Factor Xa inhibitor, blocking the propagation phase of the coagulation cascade without the need for antithrombin III.
Absolute bioavailability of approximately 50% for doses up to 10 mg.
High plasma protein binding of about 87% and a volume of distribution of approximately 21 L.
Primarily metabolized via the enzyme CYP3A4.
Eliminated via both urine and feces, with an apparent half-life of 12 hours.
Dosage depends on the indication, patient's age, serum creatinine, and body weight.
For hip or knee replacement surgery prophylaxis, the recommended dosage is 2.5 mg orally twice daily, initiated 12 to 24 hours post-surgery.
Not recommended in patients with active pathological bleeding or a known hypersensitivity to the drug.
Can cause serious side effects including bleeding, easy bruising, unusual bleeding, and in rare cases, spinal blood clots that can lead to paralysis.
Increases the risk of severe or fatal bleeding, especially when co-administered with certain medicines.
Patients should be monitored for signs of bleeding.
Can be affected by other drugs that are substrates, inhibitors, or inducers of CYP3A4 and P-gp.
There is no specific antidote for apixaban. Management of overdose involves supportive care and may include the use of prothrombin complex concentrate, activated factor VII, or recombinant factor VIIa.
Adjusted dosing may be necessary for patients with renal impairment, hepatic impairment, or in the elderly.
Not recommended during pregnancy or breastfeeding due to insufficient data on safety.
Should be stored at temperatures below 30°C, away from moisture and heat.
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- Since: 2013-11-01
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+86-13675893055
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