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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Metabolism>Factor Xa inhibitor>Apixaban
Apixaban
  • Apixaban

Apixaban NEW

Price Get Latest Price
Package 1kg 5kg 10kg
Min. Order: 1kg
Supply Ability: 20 tons
Update Time: 2024-11-01
Related documents: MSDS COA

Product Details

Product Name: Apixaban CAS No.: 503612-47-3
EC-No.: 639-684-6 Min. Order: 1kg
Purity: 98% Supply Ability: 20 tons
Release date: 2024/11/01

1. Generic and Brand Names:

  • Generic name: Apixaban

  • Brand names: Eliquis, Eliquis Starter Pack for Treatment of DVT and PE

2. Dosage Forms:

  • Oral tablet in 2.5 mg and 5 mg strengths.

3. Indications:

  • For patients with nonvalvular atrial fibrillation to reduce the risk of stroke and systemic embolism.

  • For the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE).

  • Prophylaxis of DVT, which may lead to PE, in patients who have undergone knee or hip replacement surgery.

  • Reducing the risk of recurrent DVT and PE after initial therapy.

4. Mechanism of Action:

  • Apixaban is a direct Factor Xa inhibitor, blocking the propagation phase of the coagulation cascade without the need for antithrombin III.

5. Absorption and Distribution:

  • Absolute bioavailability of approximately 50% for doses up to 10 mg.

  • High plasma protein binding of about 87% and a volume of distribution of approximately 21 L.

6. Metabolism and Elimination:

  • Primarily metabolized via the enzyme CYP3A4.

  • Eliminated via both urine and feces, with an apparent half-life of 12 hours.

7. Administration:

  • Dosage depends on the indication, patient's age, serum creatinine, and body weight.

  • For hip or knee replacement surgery prophylaxis, the recommended dosage is 2.5 mg orally twice daily, initiated 12 to 24 hours post-surgery.

8. Contraindications:

  • Not recommended in patients with active pathological bleeding or a known hypersensitivity to the drug.

9. Side Effects:

  • Can cause serious side effects including bleeding, easy bruising, unusual bleeding, and in rare cases, spinal blood clots that can lead to paralysis.

10. Warnings and Precautions:

  • Increases the risk of severe or fatal bleeding, especially when co-administered with certain medicines.

  • Patients should be monitored for signs of bleeding.

11. Drug Interactions:

  • Can be affected by other drugs that are substrates, inhibitors, or inducers of CYP3A4 and P-gp.

12. Overdose Management:

  • There is no specific antidote for apixaban. Management of overdose involves supportive care and may include the use of prothrombin complex concentrate, activated factor VII, or recombinant factor VIIa.

13. Special Populations Considerations:

  • Adjusted dosing may be necessary for patients with renal impairment, hepatic impairment, or in the elderly.

  • Not recommended during pregnancy or breastfeeding due to insufficient data on safety.

14. Storage Conditions:

  • Should be stored at temperatures below 30°C, away from moisture and heat.

15. Regulatory Approvals and Marketing:- Approved by the US FDA in 2012 for atrial fibrillation and later for other indications. - Marketed by Bristol Myers Squibb and Pfizer under the brand name Eliquis.


Company Profile Introduction

We are experts in providing raw materials, resources, customized manufacturing, and much more. We especially pride ourselves on the partnership in the manufacturing of high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients. Among them, our key client industrial sectors around the globe are: Pharmaceuticals. Cosmetics. Nutritional Supplements. And Special Chemicals.

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  • Address: Room 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Road, Gongshu District, Hangzhou, Z
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