Amodiaquine dihydrochloride dihydrate NEW
| Price | $36 | $50 | $75 |
| Package | 50mg | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Amodiaquine dihydrochloride dihydrate | CAS No.: 6398-98-7 |
| Purity: 99.9% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Amodiaquine dihydrochloride dihydrate |
| Description | Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. |
| Kinase Assay | Whole-cell competitive binding assays: Whole-cell competitive binding assays are performed in LNCaP/AR(codon-switch) (LNCaP/AR(cs)) (harbors a mixture of exogenous wild-type AR and endogenous mutant AR (T877A)) and cells propagated in Iscove's or RPMI media supplemented with 10% fetal bovine serum, or during the assay with 10% charcoal-stripped, dextran-treated fetal bovine serum (CSS). Cells are pre-incubated with 18F-FDHT, increasing concentrations (1pM to 1 μM) of cold Bicalutamide are added, and the assay is performed to measure specific uptake of 18F-FDHT (4). IC50 values are determined using a one site binding model with least squares curve fitting and R2 > 0.99. |
| In vivo | In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs[3]. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 85 mg/mL (182.9 mM) H2O : 27 mg/mL (58.1 mM) Ethanol : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | antimalarial | anti-inflammatory | CXCL2 | CCL2 | N-methyltransferase | neuroprotective | Inhibitor | Amodiaquine | Amodiaquine dihydrochloride dihydrate | Parasite | IL-1β | Nurr1 | Histone Methyltransferase | inhibit | Amodiaquin | Amodiaquine dihydrochloride Dihydrate | Amodiaquine Hydrochloride | Amodiaquin dihydrochloride Dihydrate |
| Inhibitors Related | Kaempferol | Hydroxychloroquine | Metronidazole | Famotidine | Nitazoxanide | Doxycycline | Chloroquine phosphate | Artemisinin | Benzyl benzoate | Alginic acid |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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