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Postion:Product Catalog >Amcenestrant
Amcenestrant
  • Amcenestrant

Amcenestrant NEW

Price $147 $313 $478
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-18

Product Details

Product Name: Amcenestrant CAS No.: 2114339-57-8
Purity: 99% Supply Ability: 10g
Release date: 2024/11/18

Product Introduction

Bioactivity

名稱Amcenestrant
描述Amcenestrant (SAR439859) is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation).
體外活性in vivo SAR439859 induces strong antitumor activity against a variety of BC cell lines and patient-derived xenografts, including models that harbor ERα mutations[1].
體內(nèi)活性SAR439859(orally; 2.5-25 mg/kg; twice daily for 30 days) exhibits substantial tumor-growth inhibition and displays tumor regression at the dose of 25 mg/kg/BID[1]. It is noticed that T1/2 was variable across species (1.98 h in mouse, 4.13 h in rat and 9.80 h in dog)[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 125 mg/mL (225.44 mM), Sonication is recommended.
關鍵字breast | Inhibitor | degradation | antitumor | cancer | SERD | inhibit | cross-resistance | degrader | SAR 439859 | Amcenestrant | Orally | SAR-439859 | Estrogen Receptor/ERR | nonsteroidal
相關產(chǎn)品Kaempferol | Tamoxifen | Mifepristone | Estradiol | Astragaloside IV | Estradiol benzoate | Cholesterol | Melatonin | Chrysin | Allura Red AC | Natamycin | Ethisterone
相關庫經(jīng)典已知活性庫 | 抗卵巢癌化合物庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 內(nèi)分泌激素分子庫 | 口服活性化合物庫 | 已知活性化合物庫 | 抗癌藥物庫 | 抗癌活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Product name Price   Suppliers Update time
$147.00/1mg
VIP5Y
TargetMol Chemicals Inc.
2024-11-18
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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