Product Details
| Product Name:
ALB-127158 |
CAS No.:
1173154-32-9 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | ALB-127158 |
| Description | ALB-127158(a) is a potent and selective melanin-concentrating hormone 1 (MCH 1) receptor antagonist that may potentially treat inflammatory bowel disease (IBD). |
| In vitro | ALB-127158(a) exhibits a high affinity for the MCH 1 receptor (7 nM), demonstrating significant selectivity against various G-protein coupled receptors (GPCRs), ion channels, and transporters, notably excluding the MCH 2 receptor. In vitro functional assays have validated ALB-127158(a) as a potent and selective antagonist of the MCH 1 receptor [1]. |
| In vivo | In a diet-induced obesity (DIO) mouse model and a high-fat diet (HFD) rat model, ALB-127158(a) effectively decreases body weight and food intake. At doses ranging from 5-15 mg/kg bid for mice and as low as 1.25 mg/kg po for rats, it significantly reduces weight, primarily by decreasing fat content, with weight loss exceeding 6% for doses above 1.25 mg/kg po in rats, and peaking at about 10% weight loss at 10 mg/kg. ALB-127158(a) is quickly absorbed after oral administration, reaching maximum plasma concentration between 1 and 3 hours in both lean and overweight/obese subjects; however, lower doses exhibit a trend towards slower absorption. The compound has an average half-life of 18 to 21 hours after a single dose, which extends to approximately 26 hours with multiple doses, achieving steady-state levels in 6 to 8 days of dosing in overweight/obese subjects. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | ALB 127158 | ALB127158 | ALB-127158 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$297.00/200U |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-23 |
United States