AKB-6899 NEW
| Price | $68 | $172 | $276 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: AKB-6899 | CAS No.: 1007377-55-0 |
| Purity: 97.11% | Supply Ability: 10g |
| Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | AKB-6899 |
| 描述 | AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth. |
| 體外活性 | In murine bone marrow-derived macrophages, AKB-6899 (10 μM; 24 hours) increases the levels of HIF-2α protein, with no corresponding increase in HIF-1α. AKB-6899 shows no effect on HIF-1α accumulation or VEGF production[1]. |
| 體內(nèi)活性 | In C57BL/6 mice injected with B16F10 murine melanoma cells, AKB-6899 (17.5 mg/kg; i.p.) significantly reduces tumor growth[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 95 mg/mL (327.30 mM), Sonication is recommended. |
| 關(guān)鍵字 | antiangiogenic | Inhibitor | antitumor | AKB 6899 | HIF-PH | HIF-2α | sVEGFR-1 | HIF/HIF Prolyl-Hydroxylase | HIFs | AKB-6899 | inhibit | Hypoxia-inducible factors | PHD3 |
| 相關(guān)產(chǎn)品 | Ribociclib | Deferoxamine Mesylate | Nintedanib | Hydralazine hydrochloride | Sorafenib | Glucosamine | Hydroxycitric acid tripotassium hydrate | Regorafenib | Acriflavine Hydrochloride | Pazopanib | Axitinib | Glucosamine sulfate |
| 相關(guān)庫(kù) | 抗結(jié)直腸癌化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 膜蛋白靶向化合物庫(kù) | 酪氨酸激酶分子庫(kù) | 激酶抑制劑庫(kù) | 抗癌細(xì)胞代謝庫(kù) | 抑制劑庫(kù) | 抗心血管疾病化合物庫(kù) | 已知活性化合物庫(kù) | 抗肝癌化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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