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Postion:Product Catalog >AF 12198 Acetate
AF 12198 Acetate
  • AF 12198 Acetate

AF 12198 Acetate NEW

Price $697 $1470 $1980
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: AF 12198 Acetate Purity: 95.27%
Supply Ability: 10g Release date: 2024/11/19

Product Introduction

Bioactivity

NameAF 12198 Acetate
DescriptionAF 12198 Acetate is a novel low molecular weight antagonist of IL-1
In vitro?In vitro, AF12198 inhibits IL-1-induced IL-8 production by human dermal fibroblasts with a half-maximal inhibition concentration or IC50 of 25 nM and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression by endothelial cells with an IC50 of 9 nM[1].
In vivoWhen given as an intravenous infusion to cynomolgus monkeys, AF12198 blocks ex vivo IL-1 induction of IL-6 and down modulates in vivo induction of IL-6.?This is the first small molecule to show IL-1 receptor antagonist activity in vivo[1].?
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 60 mg/ml (30.69 mM)
KeywordsAF 12198 Acetate | AF-12198 Acetate | AF12198 Acetate | 185413-30-3 | 185413-30-3 Free base
Inhibitors RelatedInosine pranobex | L-Arginine | Diallyl disulfide
Related Compound LibrariesBioactive Compound Library | Cytokine Inhibitor Library | Peptide Compound Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Recommended supplier

Product name Price   Suppliers Update time
$180.00/1mg
VIP3Y
TargetMol Chemicals Inc.
2024-10-28
$1520.00/25mg
VIP1Y
TargetMol Chemicals Inc.
2024-10-28
$1.00/20Kg/Drum
VIP4Y
CHINATECH(TIANJIN) CHEMICAL CO.,LTD.
2021-07-26
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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