Acetazolamide sodium NEW
| Price | $40 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-08 |
Product Details
| Product Name: Acetazolamide sodium | CAS No.: 1424-27-7 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/08 |
Product Introduction
Bioactivity
| 名稱 | Acetazolamide sodium |
| 描述 | Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and altitude sickness. |
| 體外活性 | The combination of Acetazolamide sodium (0-160 μM) with MS-275 (0.75 μM) exhibited dose-dependent inhibition of growth, induced cell cycle arrest and apoptosis, and reduced migration ability in NB cell line SH-SY5Y[1]. |
| 體內(nèi)活性 | In preclinical xenograft models, treatment with AZ (40 mg/kg), MS-275 (20 mg/kg), and AZ + MS-275 (40 + 20 mg/kg) for 14 days significantly inhibited tumor growth in vivo. The expression of HIF-1α and CAIX markedly decreased, while apoptosis in NB xenograft cells of SH-SY5Y significantly increased[1]. |
| 存儲(chǔ)條件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 80 mg/mL (4.08 mM), Sonication is recommended. DMSO : 80 mg/mL (4.08 mM), Sonication is recommended. |
| 相關(guān)產(chǎn)品 | Benzenesulfonamide | Urea | Cyclamic acid sodium | Orthanilamide | Tioxolone | Zonisamide | Histone acetyltransferase p300 Inhibitor 4c | EMAC10101d | pNNP | Trichlormethiazide |
| 相關(guān)庫(kù) | FDA上市及藥典收錄分子庫(kù) | 經(jīng)典已知活性庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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