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Postion:Product Catalog >Ac-YVAD-CMK
Ac-YVAD-CMK
  • Ac-YVAD-CMK

Ac-YVAD-CMK NEW

Price $64 $228 $372
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Ac-YVAD-CMK CAS No.: 178603-78-6
Purity: 99.49% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameAc-YVAD-CMK
DescriptionAc-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
In vitroAc-YVAD-cmk (40 and 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia[3].
In vivoIn SD rats, Ac-YVAD-cmk treatment (1 μg; injection into the left lateral ventricle) significantly decreases the protein levels of caspase-1 and mature IL-1β/IL-18 compared with the ICH group[3]. Ac-YVAD-cmk (12.5 μmol/kg) significantly reduces mortality from 83 to 33% in rats[4].
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 90 mg/mL (166.4 mM), Sonication is recommended.
DMF : 10 mg/mL
KeywordsAc-YVAD-CMK
Inhibitors RelatedDisulfiram | Benzyl cinnamate | Inosine pranobex | Amlexanox | Dexamethasone acetate | L-Arginine | Taurochenodeoxycholic Acid | α-Terpineol | Tauroursodeoxycholate | Diallyl disulfide | Linalool | Apilimod
Related Compound LibrariesBioactive Compound Library | Neuroprotective Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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