成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >API>Antipyretic analgesics>Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)>Diflunisal
Diflunisal
  • Diflunisal
  • Diflunisal
  • Diflunisal
  • Diflunisal
  • Diflunisal

Diflunisal

Price $9.8
Package 1KG
Min. Order: 1g
Supply Ability: 20 tons
Update Time: 2020-02-11

Product Details

Product Name: Diflunisal CAS No.: 22494-42-4
Min. Order: 1g Purity: >98%
Supply Ability: 20 tons Release date: 2020/02/11
Storage:: Keep away from heat, sparks and flames Package:: Bottle / Drum / Bag
Delivery Time:: Prompt Port:: Shanghai, Tianjin or Qingdao
Transportation:: By sea, express, air,railway Product No. :: Jessie

Jessie  808

Email: jessie@coreychem.com

Welcome to consult us!

[Product Specification]

Names

Name
diflunisal
Synonym
More Synonyms

 Diflunisal Biological Activity

Description
Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
Related Catalog
Research Areas >> Inflammation/Immunology
Target

COX

In Vivo
Administration of increasing doses of Diflunisal to rats shows that the effect of the dose on the pharmacokinetics of Diflunisal is quite complicated. The plasma concentrations of Diflunisal decline exponentially with time, albeit with a half-life that increases with increasing dose. The CLP is reduced considerably when the dose increases from 3 to 10 mg/kg and then remains relatively constant over the dose range of 10 to 60 mg/kg. Diflunisal has been shown to be highly bound to rat plasma protein and dependent on concentration. The fraction of unbound Diflunisal is increased about 10-fold over the concentration range of 5 to 300 μg/mL[1]. Diflunisal exhibits activity after oral administration with potency about 25 times greater than that of aspirin, about 3 times that of glafenine and twice that of zomepirac[2].
Animal Admin
Rats[1] For the study of dose dependency, Diflunisal is administered by i.a. injection in doses of 3, 10, 30 and 60 mg/kg (1.5, 5, 15 and 30 mg/mL dosing solution in 0.1 M NaHCO3). The infusion studies consist of a bolus injection of Diflunisal followed immediately by a 7-hr infusion at a constant rate. Seven groups of rats are included in the infusion studies. The loading doses used are 2, 3, 5, 10, 25, 50 and 80 mg/kg and their corresponding infusion rates are 3, 4.5, 9, 18, 36, 72 and 144 μg/min (0.576 mL/hr of seven different dosing solutions: 0.31, 0.47, 0.94, 1.88, 3.75, 7.5 and 15 mg/mL in 0.1 M NaHCO3). Blood samples are collected serially at appropriate times for the dose-dependency studies, but collected hourly for the infusion studies. Plasma is obtained immediately by centrifugation of blood samples and extracted with acetonitrile and then frozen (-20°C) until assay[1].
References

[1]. Lin JH, et al. Dose-dependent pharmacokinetics of diflunisal in rats: dual effects of protein binding and metabolism. J Pharmacol Exp Ther. 1985 Nov;235(2):402-6.

[2]. Winter CA, et al. Analgesic activity of diflunisal [MK-647; 5-(2,4-difluorophenyl)salicylic acid] in rats with hyperalgesia induced by Freund's adjuvant. J Pharmacol Exp Ther. 1979 Dec;211(3):678-85.

[3]. Cappon GD, et al. Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure. Birth Defects Res B Dev Reprod Toxicol. 2003 Feb;68(1):47-56.

 Chemical & Physical Properties

Density
1.4±0.1 g/cm3
Boiling Point
386.9±42.0 °C at 760 mmHg
Melting Point
32-36 °C
Molecular Formula
C13H8F2O3
Molecular Weight
250.198
Flash Point
187.8±27.9 °C
Exact Mass
250.044144
PSA
57.53000
LogP
4.44
Vapour Pressure
0.0±0.9 mmHg at 25°C
Index of Refraction
1.601
Storage condition
Refrigerator
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

You may like

Recommended supplier

Product name Price   Suppliers Update time
$30.00/25mg
VIP3Y
TargetMol Chemicals Inc.
2024-11-05
$30.00/25mg
VIP5Y
TargetMol Chemicals Inc.
2024-11-05
$0.00/1kg
VIP5Y
Hebei Yanxi Chemical Co., Ltd.
2023-10-17
$666.70/1Kg/Bag
Baoji Guokang Healthchem co.,ltd
2021-06-02
$600.00/1KG
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2020-10-14
$0.00/1KG
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2020-09-26
$1.00/1g
Cangzhou Wanyou New Material Technology Co.,Ltd
2019-08-01
  • Since: 2014-12-17
  • Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
INQUIRY