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Postion:Product Catalog >Biochemical Engineering>Chinese Herbs>Timosaponin B II
Timosaponin B II
  • Timosaponin B II
  • Timosaponin B II
  • Timosaponin B II
  • Timosaponin B II
  • Timosaponin B II

Timosaponin B II

Price $9.8
Package 1KG
Min. Order: 1g
Supply Ability: 20 tons
Update Time: 2020-02-11

Product Details

Product Name: Timosaponin B II CAS No.: 136656-07-0
Min. Order: 1g Purity: >98%
Supply Ability: 20 tons Release date: 2020/02/11
Storage:: Keep away from heat, sparks and flames Package:: Bottle / Drum / Bag
Delivery Time:: Prompt Port:: Shanghai, Tianjin or Qingdao
Transportation:: By sea, express, air,railway Product No. :: Jessie

Jessie  808

Email: jessie@coreychem.com

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[Product Specification]

Names

Name
Timosaponin B II
Synonym
More Synonyms

 Timosaponin B II Biological Activity

Description
Timosaponin BII is an antioxidant and an anti-inflammatory agent.
Related Catalog
Signaling Pathways >> Others >> Others
Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Natural Products >> Saccharides and Glycosides
In Vitro
Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells[1].
In Vivo
Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time[2].
References

[1]. Guo J, et al. Cytotoxic activities of chemical constituents from rhizomes of Anemarrhena asphodeloides and their analogues. Arch Pharm Res. 2015;38(5):598-603.

[2]. Huang JF, et al. Timosaponin-BII inhibits the up-regulation of BACE1 induced by ferric chloride in rat retina. BMC Complement Altern Med. 2012 Oct 22;12:189.

 Chemical & Physical Properties

Density
1.5±0.1 g/cm3
Boiling Point
1033.6±65.0 °C at 760 mmHg
Molecular Formula
C45H76O19
Molecular Weight
921.073
Flash Point
578.9±34.3 °C
Exact Mass
920.498108
PSA
307.37000
LogP
0.34
Vapour Pressure
0.0±0.6 mmHg at 25°C
Index of Refraction
1.627

 Synonyms

(3β,5β,25S)-26-(β-D-Glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside
Timosaponinb-II
β-D-Galactopyranoside, (3β,5β,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-
N1929
Timosaponin B2
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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