OSI-420
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 1ton |
| Update Time: | 2020-01-13 |
Product Details
| Product Name: OSI-420 | CAS No.: 183320-51-6 |
| EC-No.: 200-258-5 | Min. Order: 1g |
| Purity: 99% | Supply Ability: 1ton |
| Release date: 2020/01/13 | |
| contact: Mary@coreychem.com |
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Common Name
OSI-420
CAS Number
183320-51-6
Molecular Weight
415.870
Density
N/A
Boiling Point
N/A
Molecular Formula
C21H22ClN3O4
Melting Point
N/A
MSDS
N/A
Flash Point
N/A
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Use of OSI-420
Desmethyl Erlotinib (OSI-420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor.
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Name
2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol,hydrochloride
Synonym
More Synonyms
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Description
Desmethyl Erlotinib (OSI-420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor.
Related Catalog
Research Areas >> Cancer
In Vivo
Desmethyl Erlotinib exposure (AUC) in plasma is 30% (range 12-59%) of erlotinib, and Desmethyl Erlotinib clearance is more than 5-fold higher than erlotinib. The CSF penetration of erlotinib and Desmethyl Erlotinib is <5% relative to total plasma concentration[1].
References
[1]. Meany HJ, et al. The plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite (OSI-420) after intravenous administration of erlotinib in non-human primates. Cancer Chemother Pharmacol. 2008, 62(3), 387-392.
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Molecular Formula
C21H22ClN3O4
Molecular Weight
415.870
Exact Mass
415.129883
PSA
85.73000
LogP
3.62600
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OSI-420
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
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