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Postion:Product Catalog >Natural Products>Chalcones>Butein
Butein
  • Butein
  • Butein
  • Butein
  • Butein
  • Butein

Butein

Price $1
Package 1KG
Min. Order: 1KG
Supply Ability: 20 tons
Update Time: 2020-01-10

Product Details

Product Name: Butein CAS No.: 487-52-5
Min. Order: 1KG Purity: ≥98%
Supply Ability: 20 tons Release date: 2020/01/10
Storage:: Keep away from heat, sparks and flames Package:: Bottle / Drum / Bag
Delivery Time:: Prompt Port:: Shanghai, Tianjin or Qingdao
Transportation:: By sea, express, air,railway Product No. :: Jessie
Jessie 0523
Contact : jessie@coreychem.com
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[Product Specification]

Names

Name
butein
Synonym
More Synonyms

 Butein Biological Activity

Description
Butein, a plant polyphenol isolated from Rhus verniciflua, inhibit the activation of protein tyrosine kinase and EGFR. target: EGFR [1]In vitro: 1) Butein inhibited the activation of AKT, extracellular signal-regulated kinase (ERKs) and p38 kinases in the presence of cisplatin.[2] 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.[2]3) Butein suppresses cell proliferation and enhances apoptosis in paclitaxel-resistant ovarian cancer cells.[3]4) Butein activates FOXO3a/p27kip1 pathway in ALL cell lines.[4]5) Butein inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50= 65 μM) and p60c-src(IC50= 65 μM)In vivo: 1) Butein in combination with cisplatin suppresses tumor growth and increases FoxO3a expression.[1]
Related Catalog
Signaling Pathways >> Autophagy >> Autophagy
Natural Products >> Phenols
Research Areas >> Cancer
Target

EGFR

References

[1]. Er-Bin Yang et al. Butein, a Specific Protein Tyrosine Kinase Inhibitor. Biochem Biophys Res Commun, 1998 Apr 17, 245(2):435-8.

[2]. Zhang L et al. Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Int J Mol Med, 2015 Oct, 36(4):957-66

[3]. Hyeong Sim Choi et al. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement Altern Med, 2016, 16: 122.

[4]. Tang YL et al. Butein inhibits cell proliferation and induces cell cycle arrest in acute lymphoblastic leukemia via FOXO3a/p27kip1 pathway. Oncotarget, 2016 Apr 5, 7(14):18651-64.

 Chemical & Physical Properties

Density
1.5±0.1 g/cm3
Boiling Point
560.9±50.0 °C at 760 mmHg
Melting Point
216°C
Molecular Formula
C15H12O5
Molecular Weight
272.25
Flash Point
307.1±26.6 °C
PSA
17.07000
LogP
2.66
Appearance of Characters
solid | yellow
Vapour Pressure
0.0±1.6 mmHg at 25°C
Index of Refraction
1.748
Storage condition
-20°C
Water Solubility
DMSO: >50 mg/mL
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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