Demecarium bromide
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 1000KGS |
| Update Time: | 2019-12-23 |
Product Details
| Product Name: Demecarium bromide | CAS No.: 56-94-0 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 1000KGS | Release date: 2019/12/23 |
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Product Name:
Demecarium bromide
Synonyms:
N,N-decamethylenebis(N,N,N-trimethyl-3-methylcarbamoyloxyanilinium) dibromide;Demecarium;Trimethyl-[3-[methyl-[10-[methyl-(3-trimethylazaniumylphenoxy)carbonylamino]decyl]carbamoyl]oxyphenyl]azanium dibromide;3,3'-[1,10-Decanediylbis[(methylimino)carbonyloxy]]bis[N,N,N-trimethylbenzenaminium];trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylammonio)phenoxy]carbonyl-amino]decyl]carbamoyl]oxyphenyl]ammonium dibromide;DeMecariuM BroMide USP;2br;ammonium,(m-hydroxyphenyl)trimethyl-,bromide,decamethylenebis(methylcarbamat
CAS:
56-94-0
MF:
C32H52Br2N4O4
MW:
716.59
EINECS:
200-301-9
Product Categories:
Other APIs
Mol File:
56-94-0.mol
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Demecarium bromide Chemical Properties
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Melting point
162-167 °C (decomp)
CAS DataBase Reference
56-94-0(CAS DataBase Reference)
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Safety Information
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HS Code
2924296000
Hazardous Substances Data
56-94-0(Hazardous Substances Data)
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MSDS Information
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Provider
Language
Demecarium bromide
English
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Demecarium bromide Usage And Synthesis
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Chemical Properties
White Solid
Uses
Demecarium Bromide is an acetylcholinesterase inhibitor and veterinary medicine used to treat elevated intraocular pressure associated with primary glaucoma.
Uses
anticancer agent for pancreatic islet cells
Definition
ChEBI: The methobromide salt of the N,N'-bis[3-(dimethylamino)phenyl carbamate] derivative of 2,13-diazatetradecane. It is an inhibitor of acetylcholinesterase and pseudocholinesterase, with a long duration of action. It is u ed in the treatment of chronic open-angle glaucoma: in the eye, it causes constriction of the iris sphincter muscle and the ciliary muscle, facilitating the outflow of the aqueous humor and so reducing intraocular pressure.
Brand name
Humorsol (Merck).
General Description
Demecarium bromide,(m-hydroxyphenyl)trimethylammonium bromide, decamethylenebis[methylcarbamate] (Humorsol), is the diester of(m-hydroxyphenyl)trimethylammonium bromide with decamethylene-bis-(methylcarbamic acid) and thus is comparableto a bis-prostigmine molecule.
It occurs as a slightly hygroscopic powder that is freelysoluble in water or alcohol. Ophthalmic solutions of the drughave a pH of 5 to 7.5. Aqueous solutions are stable and maybe sterilized by heat. Its efficacy and toxicity are comparableto those of other potent anticholinesterase inhibitor drugs. Itis a long-acting miotic used to treat wide-angle glaucomaand accommodative esotropia. Maximal effect occurs hoursafter administration, and the effect may persist for days.
It occurs as a slightly hygroscopic powder that is freelysoluble in water or alcohol. Ophthalmic solutions of the drughave a pH of 5 to 7.5. Aqueous solutions are stable and maybe sterilized by heat. Its efficacy and toxicity are comparableto those of other potent anticholinesterase inhibitor drugs. Itis a long-acting miotic used to treat wide-angle glaucomaand accommodative esotropia. Maximal effect occurs hoursafter administration, and the effect may persist for days.
Veterinary Drugs and Treatments
Demecarium is a potent carbamate inhibitor that may reduce intraocular pressures for up to 48 hours in canines. Demecarium reversibly inhibits anticholinesterase thereby causing miosis. Demecarium is generally used in preventive management of the contralateral eye in canine patients after the diagnosis of an acute congestive crisis of primary glaucoma in the other eye. It is not used in secondary glaucoma. Demecarium has the advantage of once or twice daily dosing.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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