7-Nitroindazole NEW
| Price | $29 |
| Package | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: 7-Nitroindazole | CAS No.: 2942-42-9 |
| Purity: 96.15% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | 7-Nitroindazole |
| 描述 | 7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS. |
| 動物實驗 | Animals were divided into four groups (n = 12) as follows:group 1: control animals, treated with saline for 7 days, which were involved in the experiment from the very beginning and housed under the same standard laboratory conditions as the treated animals;group 2: animals, receiving 15 mg/kg?1 i.p. of cocaine for 7 days;group 3: animals, receiving 25 mg/kg?1 i.p. 7-NI for 7 days ;group 4: animals, treated with 7-NI (25 mg/kg?1 i.p.) and 30 min later with cocaine (15 mg/kg?1) for 7 days.Twenty-four hours after the last administration of the compounds the animals were observed for behavioral changes related to the withdrawal syndrome.?Then the animals were sacrificed through decapitation and brains were extracted.?Brains of six animals from each group were taken for isolation of synaptosomes and brains from the other six animals of each group were used for measurement of nNOS and antioxidant enzymes[1]. |
| 體內(nèi)活性 | In the experimental model of cocaine multiple administration in rats the selective nNOS inhibitor 7-nitroindazole not only attenuated the behavioral changes induced by cocaine deprivation but also exerted an antioxidant and neuroprotective activity.?The possible mechanisms underlying the neuroprotective effects of 7-NI could be due to the combination of its inhibitory effect of nNOS and its direct free radical scavenging properties.?The beneficial effect of 7-NI in restoration of the antioxidant cell defense in the brain, impaired by multiple cocaine administration, and along with it the attenuation of the physical dependence, induced by cocaine, once again confirm the role of the oxidative stress in the development of addiction to psychoactive compounds[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 32 mg/mL (196.16 mM) |
| 關(guān)鍵字 | Inhibitor | inhibit | 7Nitroindazole | 7 Nitroindazole | Nitric oxide synthases | 7-Nitroindazole | NO Synthase | NOS |
| 相關(guān)產(chǎn)品 | L-NAME hydrochloride | Dexamethasone acetate | Diallyl disulfide |
| 相關(guān)庫 | 非甾體類抗炎化合物庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 人代謝物化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $44.00/25mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-30 | |
| $0.00/25kg |
VIP3Y
|
Shanghai Joiny Pharmaceutical Co.,LTD
|
2023-02-14 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-06-27 | ||
| $6.68/1KG |
VIP5Y
|
Career Henan Chemical Co
|
2020-01-09 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY