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Postion:Product Catalog >API>Antibiotics>Other antibiotic Drugs>trichostatin A
trichostatin A
  • trichostatin A
  • trichostatin A
  • trichostatin A
  • trichostatin A
  • trichostatin A

trichostatin A

Price Get Latest Price
Package 1KG
Min. Order: 1g
Supply Ability: 1 ton
Update Time: 2021-03-17

Product Details

Product Name: trichostatin A CAS No.: 58880-19-6
Min. Order: 1g Purity: 99.9%
Supply Ability: 1 ton Release date: 2021/03/17

簡(jiǎn)介

曲古抑菌素A(TSA)是一種有機(jī)化合物,用作抗真菌抗生素,并選擇性地抑制I類和II類哺乳動(dòng)物組蛋白脫乙酰酶(HDAC)家族的酶,而不是III類HDAC(即sirtuins)。TSA在生長(zhǎng)階段開(kāi)始時(shí)抑制真核細(xì)胞周期。TSA可用于通過(guò)干擾去除組蛋白(組蛋白脫乙酰酶,HDAC)的乙酰基來(lái)改變基因表達(dá),從而改變DNA轉(zhuǎn)錄因子進(jìn)入染色質(zhì)內(nèi)的DNA分子的能力。它是具有廣譜表觀遺傳活性的更大類組蛋白脫乙酰酶抑制劑(HDIs或HDACI)的成員。因此,TSA具有作為抗癌藥物的一些潛力。一個(gè)建議的機(jī)理是TSA促進(jìn)凋亡相關(guān)基因的表達(dá),導(dǎo)致癌細(xì)胞以較低的速率存活,從而減緩癌癥的進(jìn)展。其他機(jī)制可能包括HDIs誘導(dǎo)細(xì)胞分化的活性,從而起到“成熟”腫瘤中發(fā)現(xiàn)的一些去分化細(xì)胞的作用。 HDI對(duì)非組蛋白效應(yīng)分子具有多重作用,因此目前尚無(wú)法了解抗癌機(jī)制。

基本信息

中文名稱
曲古柳菌素A
英文名稱
trichostatin A
中文別名

曲古抑菌素A; 曲古抑菌素;

英文別名

(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide; TRICHOSTATIN A;

CAS號(hào)
58880-19-6
分子式
C17H22N2O3
分子量
302.36800
精確質(zhì)量
302.16300
PSA
69.64000
LOGP
2.97020

物化性質(zhì)

外觀與性狀:
灰白色粉末
密度:
1.139 g/cm3
熔點(diǎn):
141-143ºC
儲(chǔ)存條件:
-20ºC

安全信息

安全說(shuō)明:
S26; S36
危險(xiǎn)類別碼:
R20/21/22
海關(guān)編碼:
2924299090
危險(xiǎn)品標(biāo)志:
Xn 

簡(jiǎn)介

曲古抑菌素A(TSA)是一種有機(jī)化合物,用作抗真菌抗生素,并選擇性地抑制I類和II類哺乳動(dòng)物組蛋白脫乙酰酶(HDAC)家族的酶,而不是III類HDAC(即sirtuins)。TSA在生長(zhǎng)階段開(kāi)始時(shí)抑制真核細(xì)胞周期。TSA可用于通過(guò)干擾去除組蛋白(組蛋白脫乙酰酶,HDAC)的乙?;鶃?lái)改變基因表達(dá),從而改變DNA轉(zhuǎn)錄因子進(jìn)入染色質(zhì)內(nèi)的DNA分子的能力。它是具有廣譜表觀遺傳活性的更大類組蛋白脫乙酰酶抑制劑(HDIs或HDACI)的成員。因此,TSA具有作為抗癌藥物的一些潛力。一個(gè)建議的機(jī)理是TSA促進(jìn)凋亡相關(guān)基因的表達(dá),導(dǎo)致癌細(xì)胞以較低的速率存活,從而減緩癌癥的進(jìn)展。其他機(jī)制可能包括HDIs誘導(dǎo)細(xì)胞分化的活性,從而起到“成熟”腫瘤中發(fā)現(xiàn)的一些去分化細(xì)胞的作用。 HDI對(duì)非組蛋白效應(yīng)分子具有多重作用,因此目前尚無(wú)法了解抗癌機(jī)制。

基本信息

中文名稱
曲古柳菌素A
英文名稱
trichostatin A
中文別名

曲古抑菌素A; 曲古抑菌素;

英文別名

(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide; TRICHOSTATIN A;

CAS號(hào)
58880-19-6
分子式
C17H22N2O3
分子量
302.36800
精確質(zhì)量
302.16300
PSA
69.64000
LOGP
2.97020

物化性質(zhì)

外觀與性狀:
灰白色粉末
密度:
1.139 g/cm3
熔點(diǎn):
141-143ºC
儲(chǔ)存條件:
-20ºC

安全信息

安全說(shuō)明:
S26; S36
危險(xiǎn)類別碼:
R20/21/22
海關(guān)編碼:
2924299090
危險(xiǎn)品標(biāo)志:
Xn

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Company Profile Introduction

Welcome to hebei Shuoxi biotechnology co., LTD. Shuoxi is a fast developing pharmaceutical intermediates enterprise located in shijiazhuang, capital of hebei province. Shuoxi analysis research and development center also provides custom synthesis service. Hebei Shuoxi biotechnology co., LTD can provide customized synthetic chemicals in different quantities in laboratories, factories and industrial scale. We have more than 10 years experience in this field. We can offer competitive price for every customer and guarantee the quality of our products. 3. We pay attention to the needs of each customer and build a good relationship with them. 4. We have long-term business relations with Canada, Mexico, Brazil, UK, Russia, Germany, USA, India, South Africa, Malta, Egypt, Armenia, Australia, Philippines, Belgium, Netherlands, Denmark and other countries. If you have any other questions for me. Please feel free to contact me. We only produce and sell products that are legal in China. All products are sold only to laboratory research.

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