Product no. chemwillID3C1007

3-Hydroxymethylindole 3-Indolemethanol  Indole-3-methanol Indole-3-carbinol  700-06-1 Manufacturer High quality Best price In stock

Indole-3-carbinol  700-06-1 In stock 3-Hydroxymethylindole 3-Indolemethanol  Indole-3-methanol

700-06-1

CAS 700-06-1

3-Hydroxymethylindole; 3-Indolemethanol; Indole-3-methanol
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Product Name:    Indole-3-carbinol
Synonyms:    
Indolemethanol; 3-(Hydroxymethyl)indole; 3-Indolemethanol; 1H-Indol-3-ylmethanol; Indole-3-methanol; 1H-Indole-3-methanol; I3C; AKOS NCG1-0099; 3-Indole methanol; Indo-3-Carbinol
CAS RN.:    
700-06-1
EINECS:    211-836-2
Molecular Weight:    147.18
Molecular Formula:    C9H9NO
Melting Point(℃):    96-99℃

Synonyms        3-Hydroxymethylindole; 3-Indolemethanol; Indole-3-methanol

Indole-3-carbinol (C9H9NO) is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables such as broccoli, cabbage, cauliflower, brussels sprouts, collard greens and kale. It is also available in dietary supplements. Indole-3-carbinol is the subject of on-going biomedical research into its possible anticarcinogenic, antioxidant, and anti-atherogenic effects. Research on indole-3-carbinol has been conducted primarily using laboratory animals and cultured cells. Limited and inconclusive human studies have been reported. A recent review of the biomedical research literature found that "evidence of an inverse association between cruciferous vegetable intake and breast or prostate cancer in humans is limited and inconsistent" and "larger randomized controlled trials are needed" to determine if supplemental indole-3-carbinol has health benefits.
Basic Info
Chemical Name    indole-3-methanol
Synonyms    
INDOLE-3-METHANOL;
3-indolemethanol;
(1H-indole-3-yl)-methanol;
3-INDOLYLMETHANOL;
3-IndoleCarbinol;
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CAS No.    700-06-1
Molecular Formula    C9H9NO
Molecular Weight    147.17400
PSA    36.02000
LogP    1.66020
Properties
Appearance & Physical State    white to off white crystals
Density    1.272 g/cm3
Boiling Point    360.6ºC at 760 mmHg
Melting Point    96-99ºC
Flash Point    171.9ºC
Storage Condition    2-8ºC
Safety Info
RTECS    NL9483000
Safety Statements    S26-S36
HS Code    2933990090
WGK Germany    3
Risk Statements    R36/38
Hazard Codes    Xi

Indole-3-carbinol Basic information
Product Name:    Indole-3-carbinol
Synonyms:    Indole-3-carbinol,99.5%;Indole-3-carbinol 98%;(1H-Indol-3-yl)-methano;Indol-3-yl-methanol;3-INDOLAMETHANOL;INDOLE-3-CARBINOL:3-INDOLE METHANOL;INDOLE-3-CARBINOL(RG);3-HYDROXYMETHYLINDOLE(INDOLE-3-CARBINOL)
CAS:    700-06-1
MF:    C9H9NO
MW:    147.17
EINECS:    211-836-2
Product Categories:    blocks;IndolesOxindoles;indole derivative;Indoles and derivatives;IndoleDerivative;Pyrroles & Indoles;Indole;Indoles;Antioxidant;Biochemistry;Simple Indoles;Nutritional Supplements;Aromatics;Heterocycles;-;Halogenated Heterocycles ,Others;pharmaceutical raw material;Inhibitors;Pyrroles & Indoles;Heterocycle-Indole series
Mol File:    700-06-1.mol
Indole-3-carbinol Structure
Indole-3-carbinol Chemical Properties
Melting point     96-99 °C(lit.)
Boiling point     267.28°C (rough estimate)
density     1.1135 (rough estimate)
refractive index     1.5670 (estimate)
storage temp.     2-8°C
form     Crystalline Powder or Flakes
color     Off-white to yellow-orange
BRN     121323
Stability:    2-80C
InChIKey    IVYPNXXAYMYVSP-UHFFFAOYSA-N
CAS DataBase Reference    700-06-1(CAS DataBase Reference)
Safety Information
Hazard Codes     Xi
Risk Statements     36/38
Safety Statements     26-36
WGK Germany     3
RTECS     NL9483000
Hazard Note     Irritant
HS Code     29339900
MSDS Information
Provider    Language
SigmaAldrich    English
ACROS    English
ALFA    English
Indole-3-carbinol Usage And Synthesis
Chemical Properties    Off-White Powder
Uses    Inhibits cancinogenesis at the initiation stage. A metabolite of 3-methylindole
Uses    antineoplastic; inhibitor of Amyloid-beta deposition
Uses    nutritional supplement
Definition    ChEBI: An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Anticancer Research    I3C is a bioactive compound majorly found in Brassica vegetables including broccoli,cauliflower, and collard greens. I3C and its derivative diindolylmethane (DIM)have been investigated for cancer prevention and treatment of breast, prostate, andovarian cancers. I3C partially modulates the tyrosine kinase/PI3K/Akt signalingpathway which leads to the prevention of lung adenocarcinoma which is induced byusing tobacco carcinogen in A/J mice. DIM transduces signaling via aryl hydrocarbon(Ah) receptor, NF-κB/Wnt/Akt/mTOR signaling pathways, cell cycle arrest,modulated cytochrome P450 enzymes, and altered angiogenetic and invasive,metastatic, and epigenetic behavior of cancer cells. Combination of DIM and I3Cinduces Nrf2-mediated phase II drug metabolizing genes (GSTm2, UGT1A1, andNQO1) and antioxidant genes (HO-1, SOD-1) (Weng et al. 2008; 2012).
Indole-3-carbinol Preparation Products And Raw materials
Raw materials    2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE