6-Thioguanine NEW
| Price | $40 | $48 | $72 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: 6-Thioguanine | CAS No.: 154-42-7 |
| Purity: 98.75% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | 6-Thioguanine |
| 描述 | 6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. |
| 體外活性 | 6-Thioguanine selectively kills BRCA2-deficient tumors in xenograft models as effectively as PARP inhibitors. It eradicates cells and tumors that have developed resistance to PARP inhibitors or cisplatin through genetic reversal via the BRCA2 gene. Additionally, 6-Thioguanine is effective in eliminating PARP inhibitor-resistant tumors with BRCA1 deficiencies. |
| 體內(nèi)活性 | 6-Thioguanine is integrated into DNA, differing from typical DNA bases as it serves as a potent UVA chromophore with a peak absorbance at 342 nm. Its incorporation alters topoisomerase II-induced DNA cleavage both in the presence and absence of etoposide. Additionally, 6-Thioguanine induces similar apoptotic responses in mismatch repair-proficient and -deficient HCT116 and HeLa cells. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (299.06 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble) |
| 關(guān)鍵字 | 6 Thioguanine | SARS coronavirus | Apoptosis | Deubiquitinase | DUBs | DNMTs | inhibit | Autophagy | Inhibitor | 6-Thioguanine | DNA Methyltransferase | 6Thioguanine | DNA MTases | SARS-CoV | Endogenous Metabolite |
| 相關(guān)產(chǎn)品 | Sucrose | Tributyrin | Glycerol | Thymidine |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗病毒庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗癌上市藥物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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