Afatinib (BIBW 2992)
Price | $1 |
Package | 1g |
Min. Order: | 1g |
Supply Ability: | 1000kgs |
Update Time: | 2019-07-31 |
Product Details
Product Name: Afatinib (BIBW 2992) | CAS No.: 439081-18-2 |
Min. Order: 1g | Purity: 99% |
Supply Ability: 1000kgs | Release date: 2019/07/31 |
Small-Molecule Targeted Anti Tumor Inhibitor API Afatinib
(CAS: 439081-18-2)
Chemical Information
Quick Details:
Product Name | Afatinib |
Molecular Formula | C24H25ClFN5O3 |
Molecular Weight | 485.94 |
Storage | 3years in -20ºC |
Targets | Abl c-Src |
Dosage | 30 nM; intraperitoneal injection |
Target | EGFR (L858R) | EGFR (wt) | EGFR (L858R/T790M) | HER2 |
IC50 | 0.4 nM | 0.5 nM | 10 nM | 14 nM |
Product Name: Afatinib
Other Names:Afatinib;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;4-[(3-chloro-4-fluorophenyl)aMino]-6-{[4-(N,N-diMethylaMino)-1-oxo-2-buten-1-yl]aMino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-;(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dime;Afatinib API;Afatinib(BIBW2992MA2);Afatinib (with 1 int.)
Model No.: ATC-136
CAS No.: 439081-18-2
Molecular Formula: C24H25ClFN5O3
Molecular Weight: 485.94
Appearance: White or Nearly White Crystalline Powder
Purity: 99%+
Product Specifications: Pharmaceutical Grade
Product Description
Afatinib (INN; trade name Gilotrif in the US and Giotrif in Europe, previously Tomtovok and Tovok) is a drug approved in United States, Europe, Taiwan, Mexico, Chile and Japan as well as other countries for the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and erbB-2 (HER2).
Applications/Usage
It has received regulatory approval for use as a treatment for non-small cell lung cancer, although there is emerging evidence to support its use in other cancers such as breast cancer.
COA Report:
Item |
Requirements |
Test Results |
Description |
Off-white powder |
Off-white powder |
Identification |
HPLC ,NMR |
Complies |
Residue on Ignition |
≤0.10% |
0.05% |
Loss on Drying |
≤0.50% |
0.15% |
Heavy Metal |
≤20ppm |
<20ppm |
Purity(HPLC) |
≥99.0% |
99.99% |
Conclusion |
It complies with EnterpriseStandard |
FEATURED PRODUCT:
No. | CAS No. | Product Name |
1 | 114977-28-5 | |
2 | 148408-66-6 | |
3 | 25316-40-9 | |
4 | 133040-01-4 | Eprosartan |
5 | 183321-74-6 | Erlotinib |
6 | 183319-69-9 | Erlotinib Hydrochloride |
7 | 159351-69-6 | Everolimus |
8 | 56296-78-7 | Fluoxetine Hydrochloride |
9 | 184475-55-6 | |
10 | 136572-09-3 | |
11 | 1441674-54-9 | Ledipasvir(Acetone) |
12 | 191732-72-6 | Lenalidomide |
13 | 21672 | |
14 | 76144-81-5 | Mildronate |
15 | 474645-27-7 | Monomethyl Auristatin E |
16 | 63121-00-6 | |
17 | 137281-23-3 | Pemetrexed Disodium |
18 | 53123-88-9 | Rapamycin |
19 | 945667-22-1 | Saxagliptin Hydrate |
20 | 709031-78-7 | Saxagliptin Hydrochloride |
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- Since: 2014-05-13
- Address: Room 2004, Oriental Century Square Tower A, East Road Yellow River, Xinhua District, Cangzhou City