Product Details
| Product Name:
WYE-354 |
CAS No.:
1062169-56-5 |
| Min. Order:
1kg |
Purity:
99% |
| Supply Ability:
ask |
Release date:
2019/07/06 |
| Product Number::
WM.801 |
| WYE-354 Basic information |
| Product Name: |
WYE-354 |
| Synonyms: |
WYE-354;4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid methyl ester;methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate;WYE-354 (Degrasyn);Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pip |
| CAS: |
1062169-56-5 |
| MF: |
C24H29N7O5 |
| MW: |
495.53096 |
| EINECS: |
-0 |
| Product Categories: |
Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;PI3K/Akt/mTOR;Inhibitors;Akt;mTOR;PI3K |
| Mol File: |
1062169-56-5.mol |
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| |
| WYE-354 Chemical Properties |
| |
| WYE-354 Usage And Synthesis |
| Uses |
A pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo. |
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| WYE-354 Preparation Products And Raw materials |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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