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Price	$1
Package	1kg

Product Details

Product Name: Celastrol	CAS No.: 34157-83-0
Min. Order: 1kg	Purity: 99%
Supply Ability: 100KG	Release date: 2019/07/06

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Celastrol Basic information

Pharmacological effects Application

Product Name:	Celastrol
Synonyms:	TRIPTERIN;CELASTROL;(2r,4as,6as,6ar,14as,14br)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid;3-HYDROXY-9BETA,13ALPHA-DIMETHYL-2-OXO-24,25,26-TRINOROLEANA-1(10),3,5,7-TETRAEN-29-OIC ACID;3-HYDROXY-24-NOR-2-OXO-1(10),3,5,7-FRIEDELATETRAEN-29-OIC ACID;Tripterine;CELASTROL(SH);Celastrol (Tripterin)
CAS:	34157-83-0
MF:	C29H38O4
MW:	450.61
EINECS:	1592732-453-0
Product Categories:	Miscellaneous Natural Products;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Natural Anti-cancer Medical Materials and It's Derivatives;ProteasomeInhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:	34157-83-0.mol

Celastrol Chemical Properties

Melting point	219-230°C
density	1.2
storage temp.	Store at -20°C
solubility	DMSO: >10mg/mL
color	red
λmax	424nm(MeOH)(lit.)
CAS DataBase Reference	34157-83-0(CAS DataBase Reference)

Safety Information

Hazard Codes	T
Risk Statements	25
Safety Statements	45-24/25
RIDADR	UN 2811 6.1 / PGIII
RTECS	YJ7900000

MSDS Information

Celastrol Usage And Synthesis

Pharmacological effects	Tripterine is a natural product with a variety of biological activity. It has a strong antioxidant effect, anti-cancer neovascularization effect as well as anti-rheumatoid effect. It is mainly isolated from the root bark of the celastraceae plant, Tripterygium wilfordii. It is one of the active ingredients contained in the rheumatoid-treatment drug Tripterygium tablet, Tripterygium Glycosides tablets and other preparations. The major activity and pharmacological effects of Tripterine: Cytotoxic activity. In vitro, it has non-specific cytotoxic activity against P388 and a group of human cancer cell lines. Immune regulation. It could significantly inhibit the formation of hemolytic plaque cells in mouse spleen cells and significantly inhibit the mice delayed-type hypersensitivity. Anti-inflammatory effect. At a dose of 0.5mg/kg, it could result in significant inhibition of the formation of rat cotton granuloma. At a dose of 0.1~1.0μg/mL, it could suppress the production of PGE2 induced by the yeast sugar; at a dose of 1.0μg/mL, it can inhibit the macrophage phagocytosis. The anti-oxidation effect of tripterine is 15 times that of tocopherol with an IC50 of 7μM. Inhibit the peroxidation occurring inside and outside of the mitochondrial membrane, direct removing the free radicals. Tripterine can extend the sleep time of mice triggered by the pentobarbital sodium. Immunosuppressive effect: inhibit the spleen cell proliferation of mice induced by PHA, ConA and LPS, further inhibiting the lymphocyte proliferation. It can inhibit the in vitro sperm fertilization capacity of guinea pig with the activity being significantly stronger than acetic acid gossypol. Anti-arthritic effect, it will inhibit the activity of interleukin-1 of inside and outside the mouse intraperitoneal macrophages, inhibit the production of interleukin-2 by mouse spleen cells and lower the level of PGE2 produced by rabbit synovial cells. Source: ChemicalBook Editorial.
Application	It is an effective proteasome inhibitor. It has been confirmed that it is capable of inducing apoptosis of cancer cells through inhibiting proteasome activity.
Chemical Properties	Orange Red Solid
Uses	antineoplastic, NO synthesis inhibitor, chaperone stimulant
Uses	An antioxidant onstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies.
Uses	An antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be
Definition	ChEBI: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. otently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
Biological Activity	Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF- α -induced NF κ B activation. Also shown to inhibit topoisomerase II activity in vitro (IC 50 = 7.41 μ M).

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

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Celastrol

Product Details

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career henan chemical co