5-Aminolevulinic acid hydrochloride NEW
| Price | $46 |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 5-Aminolevulinic acid hydrochloride | CAS No.: 5451-09-2 |
| Purity: 99.77% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 5-Aminolevulinic acid hydrochloride |
| Description | 5-Aminolevulinic acid hydrochloride (5-ALA) is an intermediate in heme biosynthesis and a universal precursor of tetrapyrroles. |
| In vitro | 5-Aminolevulinic acid (5-ALA), a non-fluorescent prodrug, facilitates the intracellular build-up of fluorescent porphyrins in malignant gliomas, aiding in their intraoperative identification and removal. A study with a median follow-up of 35.4 months (95% CI 1.0-56.7) showed that 65% (90 out of 139) of patients treated with 5-ALA achieved complete resection of contrast-enhancing tumors, compared to only 36% (47 out of 131) in those using white light, marking a significant difference of 29% (95% CI 17-40, p<0.0001). Additionally, those treated with 5-ALA exhibited a higher 6-month progression-free survival rate of 41.0% (32.8-49.2) versus 21.1% (14.0-28.2) for the white light group, a difference of 19.9% (9.1-30.7, p=0.0003, Z test). However, 5-ALA alone was deemed insufficient for achieving gross total resection without risking postoperative neurological damage. In treating functional grade III gliomas, the combination of intraoperative MRI (iMRI) with functional neuronavigation significantly outperformed the 5-ALA resection technique. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 31 mg/mL (185 mM) Ethanol : 6 mg/mL (35.8 mM) DMSO : 45 mg/mL (268.51 mM) |
| Keywords | δ-Aminolevulinic acid | Apoptosis | inhibit | Mitophagy | ALA Hydrochloride | Autophagy | 5Aminolevulinic acid hydrochloride | 5-Aminolevulinic acid Hydrochloride | Inhibitor | Endogenous Metabolite | 5 Aminolevulinic acid hydrochloride | 5-Aminolevulinic acid | Mitochondrial Autophagy |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library | Natural Product Library for HTS | FDA-Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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