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Postion:Product Catalog >5-A-RU
5-A-RU
  • 5-A-RU

5-A-RU NEW

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Package 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-04

Product Details

Product Name: 5-A-RU CAS No.: 17014-74-3
Supply Ability: 10g Release date: 2024/11/04

Product Introduction

Bioactivity

名稱5-A-RU
描述5-A-RU (5-Amino-6-(D-ribitylamino)uracil) is an early intermediate in riboflavin biosynthesis and is found in a variety of bacteria and yeast as well as plants. 5-A-RU is also a mucosal-associated invariant T (MAIT) cell activator that forms potent MAIT-activating antigens through non-enzymatic reactions with small molecules from other metabolic pathways.
體外活性METHODS: 5-A-RU plus DHA, 5-A-RU, 5-A-RU plus MeG, or 5-A-RU (0-3000μM) was used to treat mouse MAIT cells from STg (iVα19) and DTg (iVα19Vβ6) animals, and the activation of mouse MAIT cells was measured. RESULTS 5-A-RU plus MeG achieved the greatest MAIT cell activation; 5-A-RU alone also activated MAIT cells; 5-A-RU can also react with Glyx and MeG to produce pyrimidine adducts, activating mouse MAIT cells. [2]
體內(nèi)活性METHODS: 5-A-RU (100 nM, intraperitoneal injection) was administered to Vβ6-Tg mice and iVα19-Tg mice, and MAIT cell activation was measured. RESULTS MAIT cells were activated when 5-A-RU and MeG were mixed extemporaneously before in vivo injection, whereas 5-A-RU alone was unable to activate MAIT cells in mice. [2]
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
關(guān)鍵字5-A-RU | 5 A RU | 5ARU

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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