5-A-RU NEW
Price | Get Latest Price |
Package | 5mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-04 |
Product Details
Product Name: 5-A-RU | CAS No.: 17014-74-3 |
Supply Ability: 10g | Release date: 2024/11/04 |
Product Introduction
Bioactivity
名稱 | 5-A-RU |
描述 | 5-A-RU (5-Amino-6-(D-ribitylamino)uracil) is an early intermediate in riboflavin biosynthesis and is found in a variety of bacteria and yeast as well as plants. 5-A-RU is also a mucosal-associated invariant T (MAIT) cell activator that forms potent MAIT-activating antigens through non-enzymatic reactions with small molecules from other metabolic pathways. |
體外活性 | METHODS: 5-A-RU plus DHA, 5-A-RU, 5-A-RU plus MeG, or 5-A-RU (0-3000μM) was used to treat mouse MAIT cells from STg (iVα19) and DTg (iVα19Vβ6) animals, and the activation of mouse MAIT cells was measured. RESULTS 5-A-RU plus MeG achieved the greatest MAIT cell activation; 5-A-RU alone also activated MAIT cells; 5-A-RU can also react with Glyx and MeG to produce pyrimidine adducts, activating mouse MAIT cells. [2] |
體內(nèi)活性 | METHODS: 5-A-RU (100 nM, intraperitoneal injection) was administered to Vβ6-Tg mice and iVα19-Tg mice, and MAIT cell activation was measured. RESULTS MAIT cells were activated when 5-A-RU and MeG were mixed extemporaneously before in vivo injection, whereas 5-A-RU alone was unable to activate MAIT cells in mice. [2] |
存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
關(guān)鍵字 | 5-A-RU | 5 A RU | 5ARU |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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